Laura J. Mauro

Associate Professor-Cellular Physiology
495F AnSc/VetMed
1988 Fitch Avenue
St. Paul, MN 55108-6014
+1 612 624 6274

Education

  • Postdoctorate, The University of Michigan Medical School & Walther Cancer Institute, 1991, Cell Signaling
  • PhD. University of Minnesota, 1990, Animal Physiology/Neuroscience
  • MS. University of Minnesota, 1983, Veterinary Physiology

Research Interests

Reproductive function in all animals encompasses the biochemistry, endocrinology and genetics of the unique tissues that enable procreation.  An understanding of the physiological systems that regulate reproduction helps us treat the dysfunction of these tissues during disease and with exposure to environmental factors.  I conduct research with scientific teams examining the role of ovarian steroids and endocrine disruptors in reproductive cancers and other disease states.  Ongoing work with colleagues within the Physiology and Genetics division of the Animal Science department (Drs. Faulk, Saqui-Salces, Urriola) is focused on modulatory actions of methylation agents on the epigenetic landscape of reproductive tissues and the effects on reproductive function.  In collaboration with the laboratory of Dr. Carol Lange in the University of Minnesota Masonic Cancer Center, we are examining the effects of progesterone receptor (PR) signaling in the early initiation and progression of high grade serous ovarian cancer (HGSC) within the fallopian tube.  

Teaching

  • ANSC 3305: Reproductive Biology in Health and Disease
  • ANSC 4009W: Undergraduate Senior Thesis: Science in Agriculture
  • ANSC 4096: Professional Experience Program - Internship (mentor)
  • ANSC 4305/5305: Companion and Wild Species Reproduction
  • ANSC 8211: Animal Growth and Development
  • ANSC / CMB 8344: Mechanisms of Hormone Action

Outreach

  • Life Sciences Undergraduate Research Program (LSSURP)
  • Undergraduate Research Opportunity Grant Program (UROP)
  • Minority Scholar Program

Honors & Awards

Academic Appointments

  • 1993-1995 Research Investigator, University of Michigan Medical Center, Dept. of Biological Chemistry & Walther Cancer Institute
  • 1995-2000 Research Assistant Professor, University of Minnesota, Dept. of Biochemistry
  • 1996-prsnt Associate member, Masonic Cancer Center
  • 2000-2006 Assistant Professor, Univ. of Minnesota, Dept. of Animal Science-Physiology
  • 2006-prsnt Associate Professor, Univ. of Minnesota, Dept. of Animal Science

Honors

  • 1997-1998 NIH James A Shannon Director’s Award
  • 2011-2013 ASM/NSF Biology Scholar
  • 2013 National Society of Collegiate Scholars – Distinguished faculty

 Patents

  • 1998 U.S. Patent No. 5,821,084 ;"Osteoblast-testicular protein tyrosine phosphatase" Assignees: Wyeth-Ayerst Research & The Regents of the University of Michigan [Co-inventor w/ J. E. Dixon]

Grants

  • 2018-20 Minnesota Ovarian Cancer Alliance (MOCA)Targeting DNA-PK damage sensing kinases in hereditary ovarian cancer (Co-PI; with Carol A. Lange)
  • 2015 Minnesota Ovarian Cancer Alliance (MOCA)BRCA deficiency drives an enriched sex steroid milieu that promotes hereditary ovarian carcinogenesis (Co-PI)
  • 2015 Grant-In-Aid (UMN OVPR)Sex hormone dysfunction in hereditary breast & ovarian cancer (PI)
  • 2012-15 USDA/NRIModulation of fertility by GABAergic neurotransmission (Co-I)
  • 2008-10 MN Obesity Ctr/NIH-NIDDKRole of Skeletal Hormones in Adipocyte Function (PI)
  • 2007-12 NIH/NCICancer Pain: Nerve/Tumor Interactions (Co-I)
  • 2005-10 NIH/NCINegative Regulators: Key Determinants in Carcinogenesis (Co-I)
  • 1998-03 NIH/NIAMS - Function of tyrosine phosphatase, OST-PTP, in osteogenesis (PI)
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