Education
-
Postdoctorate,
Michigan Medical Center, 1991, Cell Signaling
-
Ph.D., University of Minnesota, 1990, Animal Physiology/Neuroscience
-
M.S., University of Minnesota, 1983, Veterinary Physiology
Research
Interests
The
phosphorylation and dephosphorylation of cellular proteins is a
critical component in the regulation of all biological processes.
The signaling molecules known as protein tyrosine kinases and phosphatases
are essential mediators of this type of regulation. They are responsible
for maintaining a steady-state level of specific phosphotyrosine
proteins which will influence the functional state of the cell.
Mutations or dysfunction in these molecules is associated with many
animal and human diseases including deadly bacterial infections,
diabetes, and cancer. My
laboratory studies the importance of the tyrosine phosphatases (PTPs)
in cell proliferation and differentiation. We are interested in
how certain PTPs regulate cell growth and differentiation during
the development and remodeling of bone. In addition, we are exploring
whether these molecules could serve as drug targets for skeletal
disorders, such as osteoporosis, in animals and humans.
Postdoctoral
Fellows
- Daniel
F. Morrison, Ph.D., 1997-1999
- Nambirajan
Sundaram, Ph.D., 1998-1999
Graduate
Students
- Katie
Schiller, M.S.
- Laurie A. Yunker, M.S., Molecular Vet Biosci M.S.
Undergraduates
- Amy
Swanson - University of Minnesota (2000) - UROP Grant Awardee
- Karen T. Umali - University of Minnesota (2000) - Minority
Scholar, UROP Grant Awardee
- Marie Wheeler - University of Minnesota (2000) - Directed
Research
- Emily Kishel - Cornell University (1999) - Directed Research
- Cecilia Sabol - University of Minnesota (1999) - LSSURP.
Teaching
- ANSC
3305: Reproductive Biology
- ANSC/CMB 8344: Mechanisms of Hormone Action
- BIOC 8216: Advanced Topics in Regulatory Biology
Outreach
- Life
Sciences Undergraduate Research Program (LSSURP)
- Undergraduate Research Opportunity Grant Program (UROP)
- Minority Scholar Program
Honors and Awards
- National
Institutes of Health James A. Shannon Director's Award
- 1997-99
- U.S. Patent No. 5,821,084 - "Osteoblast-testicular
protein tyrosine phosphatase" (American Home Products
Corp., Wyeth-Ayerst Research and The Regents of the University
of Michigan) - 1998
- New Investigator Travel Grant - The Endocrine Society
- 1996
Affiliations
Publications
(2002-2006)
- Refereed
Articles -
Schiller,
K.R. and L.J. Mauro. 2005. Tyrosine phosphatases as regulators
of skeletal development and metabolism. J. Cell Biochem. 2005 Oct. 1;96(2):262-77 (Review).
Warmka,
J.K., L.J. Mauro, and E.V. Wattenberg. 2004. Mitogen activated
protein kinase phosphatase-3 is a tumor promoter target in initiated
cells that express oncogenic ras. J. Biol. Chem. 279(32):33085-33092.
Yunker, L.A., A. Undersander, J. Lian, G. Stein, C.S. Carlson, and L.J. Mauro. 2004. The tyrosine phosphatase, OST-PTP, is expressed in mesenchymal progenitor cells early during skeletogenesis in the mouse. J. Cell. Biochem. 93(4):761-773.
Zeliadt,
N.A., J.K. Warmka, S.E. Winston, R. Kahler, J.J. Westendorf,
L.J. Mauro, and E.V. Wattenberg. 2004. Tumor promoter-induced
expression of the MMP-13 gene in a mouse keratinocyte model
of initiated epidermis. Biochem. Biophys. Res. Comm. 317:570-577.
Mauro, L.J.
and D. Foster. 2002. Regulators of telomerase activity. Am.
J. Respir. Cell Mol. Biol. 26: 521-524.
Wheeler,
M., M.K. Townsend, L.A. Yunker, and L.J. Mauro. 2002. Transcriptional
activation of the tyrosine phosphatase, OST-PTP, during osteoblast
differentation. J. Cell Biochem. 87:363-376 (Featured cover
article).
- Abstracts -
Okoye, N., M.R. Zillhardt, N.A. Zeliadt, E.V. Wattenberg, and L.J. Mauro. 2006. MAP kinase phosphatases-3 regulation in colorectal carcinoma. J. Minn. Acad. Sci. 69: 19 (Abstract - Winchell Undergraduate Research Symposium - Spring 2006).
Schiller, K.R., M.R. Zillhardt, A.J. Beitz, and L.J. Mauro. 2006. Regulation of CCL2 in a novel fibrosarcoma-bone co-culture model. In: Proc. of 97th Annual Meeting of AACR, Apr 2006; 63-64.
Zillhardt, M.R., A. Undersander, C.S. Carlson, and L.J. Mauro. 2006. Leptin and its neural effectors can modulate long bone growth in the chick. Poul. Sci. 85 (Suppl 1):120.
Petryk, A., W. Shawlot, M.P. Jarcho, L. Yunker, I. Leaf, L.J. Mauro, C.S. Carlson, and M.B. O’Connor. 2002. The role of twisted gastrulation in the development of axial skeleton in mice. Cell and Dev. Biol. Symp, Minneapolis, MN.
Yunker, L. A., C.S. Carlson, and L.J. Mauro. 2002. Spatial and temporal expression of the tyrosine phosphatase, OST-PTP, during osteogenesis. Amer. Soc. of Bone and Mineral Research Meeting, San Antonio, TX.
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