Education
- Post-doctorate, Mayo Clinic, Rochester, Minnesota, 1984
- Post-doctorate, University of Utah Medical School, 1977
- Ph.D., University of California, 1976
Research Interests
Immortalization of avian cells for vaccine substrates, molecular mechanisms
of cellular senescence and immortalization, regulation of cell cycle
events, cloning of growth specific sequences, avian endocrinology,
recombinant protein production.
Graduate Students
- Byung-Whi Kong, Animal Sciences - Ph.D. completed Dec. 2005
- Julan Chun, Animal Sciences - Ph.D.
- Abdorrahman Alghamdi, Veterinary Medicine - Ph.D. completed May 2005
- Robyn Milkie, CMB - Ph.D.
Teaching
- AGRI 1501: Biotechnology, People & Environment (Animal Biotechnology Section)
- AGRI 4009W: Senior Thesis ScAg
- AGRO 5999: Professional Molecular Biology Techniques Workshop
- ANSC 8131/MVB 8335: Molecular Biology Techniques
- ANSC/CMB 8340: Mechanisms of Hormone Action (co-instructor)
- ANSC 8510: Graduate Seminar
- BIOC 4185: Laboratory in Molecular Biology and Biotechnology
- MICB 4794W: Directed Research
- MICRO 4994: Directed Research
Outreach
- Director of Graduate Studies
- Faculty for summer Molecular Biology Techniques Workshop
- Minnesota Representative/Program Chair - 2006 NC-1008 Annual Meeting
Patents
- Immortalized cell lines protein production. Patent # 6,207,415 Issued 3/27/01.
- Immortalized cell lines for virus growth. Patent # 5,985,642 Issued
11/16/99.
- Immortalized cell lines for virus growth. Patent # 5,879,924 Issued
3/9/99.
- Method for immortalizing cells. Patent # 5,830,723 Issued 11/03/98.
- Immortalized cell lines for virus growth. Patent # 5,672,485 Issued
9/30/97.
Awards
- Outstanding Graduate Faculty Award, 2005-06
- Outstanding Faculty Award, Graduate Students, Department of Animal Science, 2000
Affiliations
- AvianResearch Center, University of Minnesota
- Molecular Veterinary Bioscience Graduate Program, University of Minnesota
Publications (2002-2006)
- Refereed Articles -
Christman, S.A., B.-W. Kong, M.M. Landry, H. Kim, and D.N. Foster. 2006. Contributions of differential p53 expression in the spontaneous immortalization of a chicken embryo fibroblast cell line. BMC Cell Biol. 7:27.
Hunt, H.D., R.M. Goto, D.N. Foster, L.D. Bacon, and M.M. Miller. 2006. At least one YMHCI molecule in the chicken is alloimmunogenic and dynamically expressed on spleen cells during development. Immunogenetics 58:297-307.
Kim, S-H., J. Rowe, H. Fujii. R. Jones, B. Schmierer, B-W Kong, K. Kuchler, D. Foster, D. Ish-Horowicz, and G. Peters. 2006. Upregulation of chicken p15INK4b at senescence and in the developing brain. J. Cell Sci. 119:2435-2443.
Kong B.-W., L.K. Foster, and D.N. Foster. 2006. Comparison of avian cell substrates for propagating subtype C avian metapneumovirus. Virus Res. 116:58-68.
Alghamdi, A.S. and D.N. Foster. 2005. Seminal DNase frees spermatozoa
entangled in neutrophil extracellular traps. Biol. Reprod. 73:1174-1181.
Alghamdi, A.S., D.N. Foster, C.S. Carlson, and M.H.T. Troedsson. 2005.
Nitric oxide levels and nitric oxide synthase expression in uterine
samples from mares susceptible and resistant to persistent breeding
induced endometritis. J. Reprod. Immunol. 53:230-237.
Alghamdi, A.S., S. Madill, and D.N. Foster. 2005. Seminal plasma improves fertility of frozen equine semen. Animal Reprod. Sci. 89:242-245.
Christman, S.A., B.-W. Kong, M.M. Landry, and D.N. Foster. 2005.
Chicken embryo extract mitigates growth and morphological changes in a
spontaneously immortalized chicken embryo fibroblast cell line. Poultry Sci.
84:1423-1431.
Christman, S.A., B.-W. Kong, M.M. Landry, H. Kim, and D.N. Foster.
2005. Modulations of p53 expression and its role in the converion to a fully immortalized chicken embryo fibroblast line. FEBS Letters 579:6705-6715.
Alghamdi, A.S.,
D.N. Foster, and M.H.T. Troedsson. 2004. Equine seminal plasma reduces
sperm binding to polymorphonuclear neutrophils (PMNs) and improves
the fertility of fresh semen inseminated into inflamed uteri. Reproduction
127:593-600.
You S., H. Kim, B.-W. Kong, H. Kim, and D.N. Foster. 2004. The role of MnSOD and catalase in response to antimycin A induced oxidative stress in immortal DF-1 cells. Molec. Cells. 18:220-229.
Kong, B-W., H.
Kim, and D.N. Foster. 2003. Cloning and expression analysis of chicken
phospholipid-hydroperoxide glutathione peroxidase. An. Biotech. 14:19-29.
Kong, B-W., H.
Kim, and D.N. Foster. 2003. Expression analysis and mitochondrial
targeting properties of the chicken manganese-containing superoxide
dismutase. Biochem. Biophys. Acta. 1625:98-108.
Kim, H., J. Farris,
S.A. Christman, Foster, L.K., S.M. O'Grady, and D.N. Foster. 2002.
Events in the immortalizing process of primary human mammary epithelial
cells by the catalytic subunit of telomerase. Biochem. Journal 365:765-772.
Kim, H., S. You,
L.K. Foster, J. Farris, and D.N. Foster. 2002. Expression profiles
of p53, p16INK4a/Rb, and telomere regulating genes in replicative
senescent primary human, mouse and chicken fibroblast cells. Exp.
Cell Res. 272:199-208.
LaFleur, D., H.
Kim, and D.N. Foster. 2002. Expression of the chicken homologue of
the mouse double minute 2 gene. Biochem. Biophys. Acta. 1574:277-282.
Mauro, L.J. and
D.N. Foster. 2002. Regulators of Telomerase Activity. Am. J. Respiratory
Cell Molec. Biol. 26:521-524.
Sato, N., K .
Mastuda, C. Sakuma, D.N. Foster, R.W. Oppenheim, and H. Yaginuma.
2002. Regulated gene expression in the chicken embryo by using replication-competent
retroviral vectors. J. Virology 76:1980-1985.
- Presentations at Professional Meetings -
Foster, D. 2004. Mechanisms of cellular immortalization. Biology Dept., Mankato State University, Mankato, MN. Feb. 2004.
Foster, D. 2003. Immortalization of cell substrates. College of Veterinary Medicine, University of Nebraska, Lincoln. Mar. 2003.
Foster, D. 2003. Mechanisms of cellular immortalization. Invitrogen/Gibco Corp., Grand Island, NY. Nov. 2003.
Foster, D. 2003. Mechanisms of cellular immortalization. College of Veterinary Medicine, Massey University, Palmerston North, New Zealand. Dec. 2003.
- Abstracts-
Kong, B-W., L.K. Foster, and D.N. Foster. 2006. Species specific deletion of the viral glycoprotein of avian metapneumovirus. American Virology Assoc., July 16, 2006, Madison, WI.
Kong, B-W. and D. N. Foster. 2005. Establishment of an Immortal Turkey Turbinate Cell Line as a Homologous Cellular Substrate for the Propagation of Avian Metapneumovirus American Society for Microbiology, Atlanta GA
Paulin-Curlee, G., R. Bey, R. Singer, D. Foster, R. Isaacson, and J. Reneau. 2005. Molecular epidemiology of Klebsiella pneumoniae in dairy herds. 48th AAVLD Meeting.
Paulin-Curlee, G., R. Singer, R. Bey, R. Isaacson, D. Foster, and J. Reneau. 2005 Genomic diversity in Klebsiella pneumoniae strains isolated from dairy herds. CRWAD Meeting, Chicago, IL.
Carlson, D., B.-W. Kong, A. Geurts, D. Shiroma, C. Steer, S.M. O’Grady, B. Herring, D.N. Foster, and S.C. Fahrenkrug. 2004. Transgenic and chromosome engineering in pigs. 2nd Annual International Conference on Transposition and Animal Biotechnology, Minneapolis, MN. June 1-2.
Kong, B.-W., A. Geurts, P.D. Lobitz, D.N. Foster, and S.C. Fahrenkrug. 2004. Application of the Sleeping Beauty transposon system to livestock transgenesis. Poster presentation, 2nd International Conference on Transposition, Minneapolis, MN. June 1-2.
Alghamdi, A.S., M.H.T. Troedsson, and D.N. Foster. 2003. Nitric oxide levels and nitric oxide synthase expression in uterine samples from mares susceptible and resistant to persistent breeding induced endometritis. Equine reproduction meetings, Ft. Collins, CO.
Christman, S.A., B.-W. Kong, M.M. Landry, H. Kim, and D.N. Foster. 2003. Fluctuations in the p53 and Rb/p16INK4a pathways contribute to the spontaneous immortalization of a chicken embryo fibroblast cell line. Molec. Biol Cell. (Suppl.)14: 165-166a.
Kong, B.-W., A. Geurts, P.D. Lobitz, D.N. Foster, and S.C. Fahrenkrug. 2003. Application of Sleeping Beauty transposon system to livestock transgenesis. Beckman Center for Transposon Research Symposium, Minneapolis, MN. July 2003.
Paulin-Curlee, G., R. Bey, and D. Foster. 2003. Identification and characterization of Klebsiella pneumoniae isolated from bovine mastitis samples. CRWAD Meeting, Chicago, IL.
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