Education
- Ph.D.,
Molecular, Cellular, Developmental Biology and Genetics, University
of Minnesota, 1997
- B.S., Double Major: Genetics and Cell Biology, and Microbiology, University
of Minnesota, 1990
Research
Interests
Functional
Genomics/Molecular Genetics - Research in my lab focuses on the functional
characterization and manipulation of the pig genome. Projects underway
in the lab include:
- Transposon-based
manipulation of the pig genome to develop medical products, large-animal
models of human genetic disease, and animals with enhanced agricultural
production traits.
- Microarray-based
profiling of gene-expression in pig tissues to identify candidate
genes for superior medical and agricultural performance.
- Development
of the Minnesota Animal Genome Ontology database (MANGOdb), a species
independent Comparative and Functional Genomics database for the
storage and analysis of phenotypic, genetic, and gene-expression
data (http://gnomix.ansci.umn.edu/).
Teaching
- ANSC 3509: Animal Biotechnology (course director)
- GCD 8008: Mammalian Gene Transfer (guest lecturer)
- CMB 8201: Mechanisms of Animal Health and Disease (guest lecturer)
Graduate
Program Membership
- Animal Sciences
- Bioinformatics
- Molecular Veterinary Biosciences
- Scientific Computation
- Veterinary Medicine
Professional Societies
- Society for Developmental Biology
- International Society of Differentiation
- International Society for Animal Genetics
Affiliated
Centers/Organizations/Appointments
Publications (2005-2009)
- Refereed Articles -
Clark, K.J., D.F. Carlson, M.J. Leaver, L.K. Foster, and S.C. Fahrenkrug. 2009. Passport, a native Tc1 transposon from flatfish, is functionally active in vertebrate cells. Nucleic Acids Res. 2009 Mar;37(4):1239-47. Epub 2009 Jan 9.
Kong, B.W., D.F. Carlson, S.C. Fahrenkrug, and D.N. Foster. 2008. Application of the Sleeping Beauty transposon system to avian cells. Anim Genet. 39(2):180-186.
Ni, J., K.J. Clark, S.C. Fahrenkrug, and S.C. Ekker. 2008. Transposon tools hopping in vertebrates. Briefings in Functional Genomics and Proteomics 7: 444-453.
Reed, K.M., K.M. Mendoza, B. Juneja, S.C. Fahrenkrug, S. Velleman, W. Chiang, and G.M. Strasburg. 2008. Characterization of expressed sequence tags from turkey skeletal muscle. Anim. Genet. 2008 Dec;39(6):635-44.
Alexander, L.J., B. Juneja, D. Shiroma, D. Nonneman, W. Snelling, and S.C. Fahrenkrug. 2007. Comparative and physical mapping of 111 previously reported and 105 new porcine microsatellites. Anim. Genet. 38(6):584-594.
Clark, K.J., D.F. Carlson, and S.C. Fahrenkrug. 2007. Pigs taking wing with transposons and recombinases. Genome Biol. 8, Suppl 1:S13.
Clark, K.J., D.F. Carlson, L. Foster, B-W. Kong, D.N. Foster, and S.C. Fahrenkrug. 2007. Enzymatic engineering of the porcine genome with transposons and recombinases. BMC Biotech. 7:42.
Jónsson, S.R., R.S. LaRue, M.D. Stenglein, S.C. Fahrenkrug, V. Andrésdóttir, and R.S. Harris. 2007. The restriction of zoonotic PERV transmissions by human APOBEC3G. PLoS ONE 12;2(9):e893.
Alexander, L.J., B. Juneja, and S. Fahrenkrug. 2006. Isolation and radiation hybrid mapping of 213 porcine microsatellites. Anim. Genet. 37(6):596-597.
Dvorak, C.M., G.H. Flickinger, J.A. Hendrickson, S.C. Fahrenkrug, M.P. Murtaugh, , and M.S. Rutherford. 2006. Mapping of genes expressed in activated porcine Peyer's patch. Anim Genet. 37(1):62-65.
Dvorak, C.M., M. Hårdstedt, H. Xie, M. Wang, B.J. Hering, M.P. Murtaugh, and S.C. Fahrenkrug. 2006. Transcriptional profiling of stress response in cultured porcine islets. Biochem. Biophys. Res. Commun. 357(1):118-125.
Jónsson, S.R., G. Haché, M.D. Stenglein, S.C. Fahrenkrug, V. Andrésdóttir, and R.S. Harris. 2006. Evolutionarily conserved and non-conserved retrovirus restriction activities of artiodactyl APOBEC3F proteins. Nucleic Acids Res. 34(19):5683-5694.
Lam, H.C., M. Vazquez, B. Juneja, S.C. Fahrenkrug, and D. Boley. 2006. A multi-agent approach to Gene Expression Analysis. Multi-Agent Systems for Medicine, Computational Biology, and Bioinformatics, 60-73.
Palmer, M.L., S.C. Fahrenkrug, and S.M. O'Grady. 2006. RNA interference and ion channel physiology. Cell Biochem. Biophys. 6(2):175-191.
Palmer, M.L., S.Y. Lee, D. Carlson, S. Fahrenkrug, and S.M. O'Grady. 2006. Stable knockdown of CFTR establishes a role for the channel in P2Y receptor-stimulated anion secretion. J. Cell Physiol. 206(3):759-770.
Palmer, M.L., S.Y. Lee, P.J. Maniak, D. Carlson, S.C. Fahrenkrug, and S.M. O'Grady. 2006. Protease-activated receptor regulation of Cl- secretion in Calu-3 cells requires prostaglandin release and CFTR activation. Am. J. Physiol. Cell Physiol. 90(4):1189-1198.
Dvorak, C.M., K.A. Hyland, J.G. Machado, Y. Zhang, S.C. Fahrenkrug, and M.P. Murtaugh. 2005. Gene discovery and expression profiling in porcine Peyer's patch. Vet. Immunol. Immunopathol. 105(3-4):301-315.
Fahrenkrug, S.,
M. Wagner, L. Morrison, and L.J. Alexander. 2005. Map assignments
of 373 previously unreported porcine microsatellites. Anim. Genet. 36(1):76-86.
Geyi Liu, G., A.M. Geurts,
K. Yae, A.R. Srinivasan, S.C. Fahrenkrug, D.A. Largaespada, J. Takeda, K. Horie, W.K. Olson, and P.B. Hackett. 2005. Target-site
preferences of sleeping beauty transposons. J. Mol. Biol. 346(1):161-173.
- Abstracts -
Carlson, D.F., K.J. Clark, and S.C. Fahrenkrug. 2008. Enzymatic engineering of the pig genome with transposons and recombinases. Model Organisms to Human Biology, San Diego, CA.
Carlson, D.F., A.M. Geurts, M. Palmer, C. Won Park, C. Steer, S. O’Grady, D.A. Largaespada, and S.C. Fahrenkrug. 2008. Highly efficient germline transgenesis and RNA interference by methylated Sleeping Beauty transposons. Model Organisms to Human Biology, San Diego, CA.
Cockrum, R.R., K.J. Austin, P.A. Ludden, J.F. Taylor, J.R. Garbe, S.C. Fahrenkrug, and K.M. Cammack. 2008. Effects of subacute dietary nitrate on production and gene expression in Suffolk ewes. ASAS Midwest Section, Des Moines, IA.
Ernst, C.W., J.P. Steibel, A.M. Ramos, J.K. Lunney, M. Wysocki, D. Petry, R.K. Johnson, S.C. Fahrenkrug, R.J. Tempelman, M.F. Rothschild, B.S. Juneja, J. Garbe, C.G. Elsik, R.O. Bates, E.E. Helman, B.L. Varnes, and M.E. Doumit. 2008. Assessment of the swine protein-annotated oligonucleotide microarray and utility of the arrays for eQTL and transcriptional profiling studies. Plant and Anim. Genome XVI, San Diego, CA.
Hsieh, C-J., C.E. Clarkson, B. Ziemba, J. Dutton, M. Firpo, T.D. O'Brien, and S.C. Fahrenkrug. 2008. Towards porcine induced pluripotent stem cells (iPS) for biomedical model development. World Stem Cell Summit, Madison, WI.
Kim, J.W., B. Juneja, J. Garbe, S.C. Fahrenkrug, C.G. Elsik, R.D. Schnabel, E. Antoniou, J.M. Reecy, R.D. Wolfinger, D.H. Keisler, and J.F. Taylor. 2008. Differential gene expression for feed efficiency detected among 6 different Angus tissues using a 24K bovine oligonucleotide microarray. Plant and Anim. Genome XVI, San Diego, CA.
Steibel, J.P., A.M. Ramos, R.J. Tempelman, R.O. Bates, M. Wysocki, J.K. Lunney, D. Petry, R.K. Johnson, S.C. Fahrenkrug, B.S. Juneja, J. Garbe, M.F. Rothschild, C.G. Elsik, and C.W. Ernst. 2008. Assessment of the swine protein-annotated oligonucleotide microarray by utilizing designed control features included on the array. Plant and Anim. Genome XVI, San Diego, CA.
|
