Education
- Ph.D.,
Molecular, Cellular, Developmental Biology and Genetics, University
of Minnesota, 1997
- B.S., Double Major: Genetics and Cell Biology, and Microbiology, University
of Minnesota, 1990
Research
Interests
Functional Genomics/Molecular Genetics - Research in my lab focuses on the functional characterization, selection, and precise modification of livestock genomes. Projects underway in the lab include:
- Genetic analysis of livestock genomes to identify polymorphisms associated with superior production traits, including; feed conversion efficiency, reproductive performance, and disease resistance.
- Profiling of livestock gene-expression to identify candidate gene products associated with biomedical and production traits.
- Precise gene addition and editing of livestock genomes to develop medical products, large-animal models of human genetic disease, and animals with enhanced agricultural production traits.
- Development of computational and bioinformatic tools to assist in livestock genetic improvement.
Teaching
- ANSC 3509: Animal Biotechnology (course director)
- BIOL 1905: Freshman Seminar - Genomics (guest lecturer)
- GCD 8008: Mammalian Gene Transfer and Expression (guest lecturer)
- CMB 8201: Mechanisms of Animal Health and Disease (guest lecturer)
Graduate
Program Membership
- Animal Sciences
- Bioinformatics
- Molecular Veterinary Biosciences
- Scientific Computation
- Veterinary Medicine
Professional Societies
- Society for Developmental Biology
- International Society of Differentiation
- International Society for Animal Genetics
Affiliated
Centers/Organizations/Appointments
Publications (2007-2011)
- Refereed Articles -
Carlson, D.F., J.R. Garbe, W. Tan, M.J. Martin, J.R. Dobrinsky, K.J. Clark, and S.C. Fahrenkrug. 2011. Strategies for selection marker-free swine transgenesis using the Sleeping Beauty transposon system. Transgenic Res. Jan. 9 [Epub ahead of print].
Carlson, D.F., A.M. Geurts, C.W. Park, A. Rangel-Filho, L. Mátés, Z. Iszvák, Z. Ivics, S.M. O’Grady, H.J. Jacob, C.J. Steer, D.A. Largaespada, S.C. Fahrenkrug. 2010. Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition. Transgenic Res. 20(1):29-45.
Cockrum, R.R., K.J. Austin, J.W. Kim, J.R. Garbe, S.C. Fahrenkrug, J.F. Taylor, and K.M. Cammack. 2010. Differential gene expression of ewes highly tolerant and lowly tolerant to elevated dietary nitrate. J. Anim. Sci. 88(10):3187-97.
Fahrenkrug, S.C., A. Blake, D.F. Carlson, T. Doran, A. Van Eenennaam, D. Faber, C. Galli, Q. Gao, P.B. Hackett, N. Li, E.A. Maga, W.M. Muir, J.D. Murray, D. Shi, R. Stotish, E. Sullivan, J.F. Taylor, M. Walton, M. Wheeler, B. Whitelaw, and B.P. Glenn. 2010. Invited Perspective. Precision genetics for complex objectives in animal agriculture. J. Anim. Sci. 88(7):2530-9.
Garbe, J.R., C.G. Elsik, E. Antoniou, J.M. Reecy, K.J. Clark, A. Venkatraman, J. Kim, R.D. Schnabel, C.M. Dickens, R.D. Wolfinger, J.F. Taylor, and S.C. Fahrenkrug. 2010. Development and application of bovine and porcine oligonucleotide arrays with protein based annotation. J. Biomed. Biotechnol. Vol. 2010:453638. doi:10.1155/2010/453638.
Carriquiry, M., W.J. Weber, S.C. Fahrenkrug, and B.A. Crooker. 2009. Hepatic gene expression in multiparous Holstein cows treated with bovine somatotropin and fed n-3 fatty acids in early lactation. J. Dairy Sci. 92(10):4889-900.
Clark, K.J., D.F. Carlson, M.J. Leaver, L.K. Foster, and S.C. Fahrenkrug. 2009. Passport, a native Tc1 transposon from flatfish, is functionally active in vertebrate cells. Nucleic Acids Res. 2009 Mar;37(4):1239-47. Epub 2009 Jan 9.
Kong, B.W., D.F. Carlson, S.C. Fahrenkrug, and D.N. Foster. 2008. Application of the Sleeping Beauty transposon system to avian cells. Anim Genet. 39(2):180-186.
Ni, J., K.J. Clark, S.C. Fahrenkrug, and S.C. Ekker. 2008. Transposon tools hopping in vertebrates. Briefings in Functional Genomics and Proteomics 7: 444-453.
Reed, K.M., K.M. Mendoza, B. Juneja, S.C. Fahrenkrug, S. Velleman, W. Chiang, and G.M. Strasburg. 2008. Characterization of expressed sequence tags from turkey skeletal muscle. Anim. Genet. 2008 Dec;39(6):635-44.
Alexander, L.J., B. Juneja, D. Shiroma, D. Nonneman, W. Snelling, and S.C. Fahrenkrug. 2007. Comparative and physical mapping of 111 previously reported and 105 new porcine microsatellites. Anim. Genet. 38(6):584-594.
Clark, K.J., D.F. Carlson, and S.C. Fahrenkrug. 2007. Pigs taking wing with transposons and recombinases. Genome Biol. 8, Suppl 1:S13.
Clark, K.J., D.F. Carlson, L. Foster, B-W. Kong, D.N. Foster, and S.C. Fahrenkrug. 2007. Enzymatic engineering of the porcine genome with transposons and recombinases. BMC Biotech. 7:42.
Jónsson, S.R., R.S. LaRue, M.D. Stenglein, S.C. Fahrenkrug, V. Andrésdóttir, and R.S. Harris. 2007. The restriction of zoonotic PERV transmissions by human APOBEC3G. PLoS ONE 12;2(9):e893.
- Abstracts -
Carlson, D.F. and S.C. Fahrenkrug. 2010. Using transposons to increase the efficiency of embryo and cellular transgenesis. Transgenic Res. 19:132-133.
Carlson, D.F., W. Tan, J.R. Garbe, and S.C. Fahrenkrug. 2010. Selection marker-free swine transgenesis using the Sleeping Beauty transposon system. FASEB Summer Res. Conf., Genome Engineering: Research and Therapeutic Applications, Steamboat Springs, CO. June 6-11.
Cockrum, R.R., K.J. Austin, J.W. Kim, J.R. Garbe, S.C. Fahrenkrug, J.F. Taylor, and K.M. Cammack. 2010. Differential gene expression of ewes highly tolerant and lowly tolerant to elevated dietary nitrate. Plant and Animal Genomes XVIII Conf., San Diego, CA.
Carlson, D.F. and S.C. Fahrenkrug. 2009. Using transposons to increase the efficiency of embryo and cellular transgenesis. UC Davis Transgenic Animal Res. Conf. VII, Tahoe City, CA. Aug. 17-21.
Carlson, D.F., K.J. Clark, and S.C. Fahrenkrug. 2008. Enzymatic engineering of the pig genome with transposons and recombinases. Model Organisms to Human Biology, San Diego, CA.
Carlson, D.F., A.M. Geurts, M. Palmer, C. Won Park, C. Steer, S. O’Grady, D.A. Largaespada, and S.C. Fahrenkrug. 2008. Highly efficient germline transgenesis and RNA interference by methylated Sleeping Beauty transposons. Model Organisms to Human Biology, San Diego, CA.
Cockrum, R.R., K.J. Austin, P.A. Ludden, J.F. Taylor, J.R. Garbe, S.C. Fahrenkrug, and K.M. Cammack. 2008. Effects of subacute dietary nitrate on production and gene expression in Suffolk ewes. ASAS Midwest Section, Des Moines, IA.
Ernst, C.W., J.P. Steibel, A.M. Ramos, J.K. Lunney, M. Wysocki, D. Petry, R.K. Johnson, S.C. Fahrenkrug, R.J. Tempelman, M.F. Rothschild, B.S. Juneja, J. Garbe, C.G. Elsik, R.O. Bates, E.E. Helman, B.L. Varnes, and M.E. Doumit. 2008. Assessment of the swine protein-annotated oligonucleotide microarray and utility of the arrays for eQTL and transcriptional profiling studies. Plant and Anim. Genome XVI, San Diego, CA.
Hsieh, C-J., C.E. Clarkson, B. Ziemba, J. Dutton, M. Firpo, T.D. O'Brien, and S.C. Fahrenkrug. 2008. Towards porcine induced pluripotent stem cells (iPS) for biomedical model development. World Stem Cell Summit, Madison, WI.
Kim, J.W., B. Juneja, J. Garbe, S.C. Fahrenkrug, C.G. Elsik, R.D. Schnabel, E. Antoniou, J.M. Reecy, R.D. Wolfinger, D.H. Keisler, and J.F. Taylor. 2008. Differential gene expression for feed efficiency detected among 6 different Angus tissues using a 24K bovine oligonucleotide microarray. Plant and Anim. Genome XVI, San Diego, CA.
Steibel, J.P., A.M. Ramos, R.J. Tempelman, R.O. Bates, M. Wysocki, J.K. Lunney, D. Petry, R.K. Johnson, S.C. Fahrenkrug, B.S. Juneja, J. Garbe, M.F. Rothschild, C.G. Elsik, and C.W. Ernst. 2008. Assessment of the swine protein-annotated oligonucleotide microarray by utilizing designed control features included on the array. Plant and Anim. Genome XVI, San Diego, CA.
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