Education
- Ph.D.,
Molecular, Cellular, Developmental Biology and Genetics, University
of Minnesota, 1997
- B.S., Double Major: Genetics and Cell Biology, and Microbiology, University
of Minnesota, 1990
Research
Interests
Functional
Genomics/Molecular Genetics - Research in my lab focuses on the functional
characterization and manipulation of the pig genome. Projects underway
in the lab include:
- Transposon-based
manipulation of the pig genome to develop medical products, large-animal
models of human genetic disease, and animals with enhanced agricultural
production traits.
- Microarray-based
profiling of gene-expression in pig tissues to identify candidate
genes for superior medical and agricultural performance.
- Development
of the Minnesota Animal Genome Ontology database (MANGOdb), a species
independent Comparative and Functional Genomics database for the
storage and analysis of phenotypic, genetic, and gene-expression
data (http://gnomix.ansci.umn.edu/).
Teaching
- ANSC/MVB
5200: Statistical Genetics and Genomics (guest lecturer)
- ANSC 3305: Reproductive Biology (guest lecturer)
- ANSC 3509: Animal Biotechnology
- ANSC 5200: Statistical Genetics and Genomics (guest lecturer)
- MVB 8201: Mechanisms of Animal Health and Disease (guest lecturer)
- AGRI 1910W: Freshman Seminar: Topics in Genomics
- AGRI 5999: Molecular Biology Workshop
- ABC Bioinformatics Workshop
Graduate
Training
- Graduate
Faculty of Animal Science
- Graduate Faculty of Molecular Veterinary Biosciences
- Graduate Faculty of Graduate Program in Bioinformatics
Professional Societies
- Society for Developmental Biology
- International Society of Differentiation
- International Society for Animal Genetics
Affiliated
Centers/Organizations/Appointments
Publications (2003-2007)
- Refereed Articles -
Alexander, L.J., B. Juneja, D. Shiroma, D. Nonneman, W. Snelling, and S.C. Fahrenkrug. 2007. Comparative and physical mapping of 111 previously reported and 105 new porcine microsatellites. Anim. Genet. 38(6):584-94.
Clark, K.J., D.F. Carlson, and S.C. Fahrenkrug. 2007. Pigs taking wing with transposons and recombinases. Genome Biol. 8, Suppl 1:S13.
Clark, K.J., D.F. Carlson, L.K. Foster, B.W. Kong, D.N. Foster, and S.C. Fahrenkrug. 2007. Enzymatic engineering of the porcine genome with transposons and recombinases. BMC Biotechnol. 7:42.
Dvorak, C.M., M. Hårdstedt, H. Xie, M. Wang, K.K. Papas, B.J. Hering, M.P. Murtaugh, and S.C. Fahrenkrug. 2007. Transcriptional profiling of stress response in cultured porcine islets. Biochem. Biophys. Res. Commun. 357(1):118-25.
Jónsson, S.R., R.S. LaRue, M.D. Stenglein, S.C. Fahrenkrug, V. Andrésdóttir, and R.S. Harris. 2007. The restriction of zoonotic PERV transmission by human APOBEC3G. PLoS ONE 2(9):e893.
Alexander, L.J., B. Juneja, and S. Fahrenkrug. 2006. Isolation and radiation hybrid mapping of 213 porcine microsatellites. Anim. Genet. 37(6):596-7.
Jónsson, S.R., G. Haché, M.D. Stenglein, S.C. Fahrenkrug, V. Andrésdóttir, and R.S. Harris. 2006. Evolutionarily conserved and non-conserved retrovirus restriction activities of artiodactyl APOBEC3F proteins. Nucleic Acids Res. 34(19):5683-94.
Palmer, M.L., S.C. Fahrenkrug, and S.M. O'Grady. 2006. RNA interference and ion channel physiology. Cell Biochem. Biophys. 46(2):175-91.
Palmer, M.L., Lee, S.Y., Carlson, D., Fahrenkrug, S., and O'Grady, S.M. 2006. Stable knockdown of CFTR establishes a role for the channel in P2Y receptor-stimulated anion secretion. J. Cell Physiol. 2006 Mar;206(3):759-70.
Palmer, M.L., Lee, S.Y., Maniak, P.J., Carlson, D., Fahrenkrug, S.C., and O'Grady, S.M. 2006. Protease-activated receptor regulation of Cl- secretion in Calu-3 cells requires prostaglandin release and CFTR activation. Am. J. Physiol. Cell Physiol. 2006 Apr;290(4):C1189-98.
Dvorak, C.M., Flickinger, G.H., Hendrickson, J.A., Fahrenkrug, S.C., Murtaugh, M.P., and Rutherford, M.S. 2006. Mapping of genes expressed in activated porcine Peyer's patch. Anim Genet. 2006 Feb;37(1):62-5.
Dvorak, C.M., Hyland, K.A., Machado, J.G., Zhang, Y, Fahrenkrug, S.C., and Murtaugh, M.P. 2005. Gene discovery and expression profiling in porcine Peyer's patch. Vet. Immunol. Immunopathol. 2005 May 15;105(3-4):301-15.
Fahrenkrug, S.,
Wagner, M., Morrison, L., and Alexander, L.J. 2005. Map assignments
of 373 previously unreported porcine microsatellites. Anim. Genet. 2005
Feb;36(1):76-86.
Liu, G., Geurts,
A.M., Yae, K., Srinivasan, A.R., Fahrenkrug, S.C., Largaespada, D.A., Takeda, J., Horie, K., Olson, W.K., and Hackett, P.B. 2005. Target-site
preferences of sleeping beauty transposons. J. Mol. Biol. 2005 Feb
11;346(1):161-73. Epub 2004 Dec 30.
Klee, E.W., Carlson,
D.F., Fahrenkrug, S.C., Ekker, S.C., and Ellis, L.B. 2004. Identifying
secretomes in people, pufferfish and pigs. Nucleic Acids Res. 2004 Feb
27;32(4):1414-1421. Print 2004.
Nadershahi, A.,
Fahrenkrug, S.C., and Ellis, L.B. 2004. Comparison of computational
methods for identifying translation initiation sites in EST data. BMC
Bioinformatics. 2004 Feb 16;5(1):14.
Robalino, J., Joshi,
B., Fahrenkrug, S.C., and Jagus, R. 2004. Two zebrafish eIF4E family
members are differentially expressed and functionally divergent. J.
Biol. Chem. 2004 Mar 12;279(11):10532-10541.
Boland, L.M., Jiang,
M., Lee, S.Y., Fahrenkrug, S.C., Harnett, M.T., and O'Grady, S.M.
2003. Functional properties of a brain specific NH2-terminally spliced
modulator of Kv4 channels. Am. J. Physiol. Cell Physiol. 2003 Jul;285(1):C161-170.
- Invited Papers, Conference Proceedings, Research Reports -
Fahrenkrug, S.C. 2004. Development of information systems to link genetic, phenotypic and environmental information. 9th DISCOVER Conference on Food Animal Agriculture – Protecting and Managing Animal Genetic Resources for Future Generations: The Next Steps, Cheyenne, WY. Nov. 2-5.
Fahrenkrug, S.C. 2004. Interface between molecular genetics and swine nutrition. Proc., 65th Minnesota Nutrition Conference, St. Paul, MN. Sep. 21-22.
Fahrenkrug, S.C. 2004. Monitoring and manipulating porcine islet gene-expression. Diabetes Institute For Immunology and Transplantation, University of Minnesota. Oct. 6.
Fahrenkrug, S.C. 2004. Resources for bovine functional genomics. The Environmental Impact of Agriculture and Energy Use: How New Technologies, Including Biotechnology, Can Provide Sustainable Solutions - Genomics and Biomass/Bioenergy Conference, Staur Gjestegård, Stange, Norway. Aug.
McIvor, R.S., P.B. Hackett, S.C. Ekker, K.J. Wangensteen, S.C. Fahrenkrug, D. Carlson, G. Zeng, X. Wang, J. Tolar, B.R. Blazar, J.L. Frandsen, L.R. Belur, and A.C. Wilber. 2004. Bioluminescence imaging in the study of Sleeping Beauty-mediated gene transfer and expression in vivo. 3rd Annual Gene Therapy Symposium for Heart, Lung, and Blood Diseases, Sonoma, CA. Nov. 17-19.
- Abstracts -
Carlson, D., B.-W. Kong, A. Geurts, D. Shiroma, C. Steer, S.M. O’Grady, B. Herring, D.N. Foster, and S.C. Fahrenkrug. 2004. Transgenic and chromosome engineering in pigs. 2nd Annual International Conference on Transposition and Animal Biotechnology, Minneapolis, MN. June 1-2.
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