Research Interests
Utilizing molecular
biology and muscle cell culture methodologies to study the regulation
of muscle growth during embryonic and postnatal growth of economically-important
animals, currently focusing on the two research areas: 1) Mechanism
of Action of Anabolic Steroid Growth Promoters, 2) Role
of Insulin-like Growth Factor Binding Proteins in Growth and Differentiation
of Pig Muscle Cells.
Teaching
- ANSC 3511: Animal Growth and Development
- ANSC 8344: Mechanisms of Hormone Action (guest lecturer)
Current Graduate Student and Post-doctoral Supervision
- Melvin Pagan (co-supervise),
Post-doctorate
- Ernest I. Kamanga-Sollo (co-supervise), Post-doctorate
- Mary Pampush (co-supervise), Post-doctorate
- Xi Gang (co-supervise), Ph.D. candidate
Professional
Activities and Honorary Societies
- Member,
Committee to Rewrite the NC-131 Regional Project
- Member,
Tech. Comm. NC-131 Regional Project, Molecular Mechanisms Regulating
Skeletal Muscle Growth and Differentiation
- Reviewer,
USDA Competitive Grant Proposals
- Student
Advisor, President's Distinguished Faculty Mentor Program
- Member,
American Society of Animal Science
- Phi
Kappa Phi
- Gamma
Sigma Delta
Publications
(2003-2007)
- Refereed Articles -
Xi, G., M.R. Hathaway, W.R. Dayton, and M.E. White. 2007. Growth factor messenger ribonucleic acid expression during differentiation of porcine embryonic myogenic cells. J. Anim. Sci. 85 143-150.
Xi, G., M.R. Hathaway, M.E. White, and W.R. Dayton. 2006. Localization of insulin-like growth factor (IGFBP)-3 in cultured porcine embryonic myogenic cells before and after TGF-beta(1) treatment. Domest. Anim. Endocrinol. PMID: 17049199.
Xi, G., E. Kamanga-Sollo, M.R. Hathaway, W.R. Dayton, and M.E. White. 2006. Effect of constitutive expression of porcine IGFBP-3 on proliferation and differentiation of L6 myogenic cells. Domest. Anim. Endocrinol. 31:35-51.
Kamanga-Sollo, E, M.S. Pampusch, M.E. White, M.R. Hathaway, and W.R. Dayton. 2005. Insulin-like growth factor binding protein (IGFBP)-3 and IGFBP-5 mediate TGF β- and myostatin-induced suppression of proliferation in porcine embryonic myogenic cell cultures. Exper. Cell Res. 311:167-176.
Xi, G., E. Kamanga-Sollo, M.R. Hathaway, W.R. Dayton, and M.E. White. 2005. Effect of constitutive expression of porcine IGFBP-3 on proliferation and differentiation of L6 myogenic cells. Domest. Anim. Endocrinol. 2005 Oct. 3.
Pampusch, M.S., G. Xi, E. Kamanga-Sollo, K.J. Loseth, M.R. Hathaway, W.R. Dayton, and M.E. White. 2005. Production of recombinant porcine IGF-binding protein-5 (IGFBP-5) and its effect on proliferation of porcine embryonic myoblast cultures (PEMC) in the presence and absence of IGF-I and Long-R3-IGF-I. J. Endocrinol. Apr. 185(1):197-206.
Kamanga-Sollo, E., M.S. Pampusch, G. Xi, M.E. White, M.R. Hathaway, and W.R. Dayton. 2004. IGF-I mRNA levels in bovine satellite cell cultures: Effects of fusion and anabolic steroid treatment. J. Cell. Physiol. 201:181-189.
Xi, G., E. Kamanga
Sollo, M.S. Pampusch, M.E. White, M.R. Hathaway, and W.R. Dayton.
2004. Effect of recombinant porcine IGFBP-3 on IGF-I and Long-R3-IGF-I stimulated proliferation and differentiation of L6 myogenic cells.
J. Cell. Physiol. 200:387-394.
Hathaway, M.R.,
W.R. Dayton, M.E. White, and M.S. Pampusch. 2003. Effects of antimicrobials
and weaning on porcine serum insulin like growth factor binding protein
levels. J. Anim. Sci. 2003 Jun;81(6):1456 63.
Johnson, B.J.,
M.E. White, M R. Hathaway, and W.R. Dayton. 2003. Effect of differentiation
on levels of insulin like growth factor binding protein mRNAs in cultured
porcine embryonic myogenic cells. Domest. Anim. Endocrinol. 2003 Jan;24(1):81
93.
Kamanga Sollo,
E., M.S. Pampusch, M.E. White, and W.R. Dayton. 2003. Role of insulin
like growth factor binding protein (IGFBP) 3 in TGF beta and GDF 8
(myostatin) induced suppression of proliferation in porcine embryonic
myogenic cell cultures. J. Cell Physiol. 2003 Nov;197(2):225 31.
Pampusch, M.S.,
B.J. Johnson, M.E. White, M.R. Hathaway, J.D. Dunn, A.T. Waylan,
and W.R. Dayton. 2003. Time course of changes in growth factor mRNA
levels in muscle of steroid implanted and nonimplanted steers. J.
Anim. Sci. 2003 Nov;81(11):2733 40.
Pampusch, M.S.,
E. Kamanga Sollo, M.E. White, M.R. Hathaway, and W.R. Dayton. 2003.
Effect of recombinant porcine IGF binding protein 3 on proliferation
of embryonic porcine myogenic cell cultures in the presence and absence
of IGF I. J. Endocrinol. 2003 Feb;176(2):227 35.
White, M.E.,
B.J. Johnson, M.R. Hathaway, and W.R. Dayton. 2003. Growth factor
messenger RNA levels in muscle and liver of steroid implanted andnonimplanted
steers. J. Anim. Sci. 2003 Apr;81(4):965 72.
- Abstracts -
Xi, G., M.R. Hathaway, M.E. White, E.I. Kamanga-Sollo, M.S. Pampusch, and W.R. Dayton. 2006. Use of RNA interference (RNAi) to silence IGFBP-3 and IGFBP-5 expression in porcine embryonic myogenic cell cultures. J. Anim. Sci. Vol. 84: 29 Suppl. 15.
Xi, G., E. Kamanga-Sollo, M.R. Hathaway, M.E. White, and W.R. Dayton. 2006. Localization of IGFBP-3 and IGFBP-5 in cultured porcine embryonic myogenic cells. J. Anim. Sci. Vol. 84: 29 Suppl. 15.
Kamanga -Sollo, E., M.E. White, M.R. Hathaway, and W.R. Dayton. 2005. Insulin-like growth factor binding protein (IGFBP)-3 and IGFBP-5 mediate TGF beta- and myostatin-induced suppression of proliferation in porcine embryonic myogenic cell cultures. J. Anim. Sci. 83 (Suppl. 1):281 (Abstract).
Xi, G., E. Kamanga -Sollo, M.R. Hathaway, M.E. White, and W.R. Dayton. 2005. Effects of constitutive expression of porcine IGFBP-3 on proliferation and differentiation of L6 myogenic cells. J. Anim. Sci. 83 (Suppl. 1):282 (Abstract).
Xi, G., M.E. White, M.R. Hathaway, and W.R. Dayton. 2005. Time course of growth factor mRNA expression during differentiation of porcine embryonic myogenic cells. J. Anim. Sci. 83 (Suppl. 1):23 (Abstract).
Kamanga-Sollo, E., M.S. Pampusch, G. Xi, M.E. White, M.R. Hathaway, and W.R. Dayton. 2004. IGF-I mRNA levels in bovine satellite cell cultures: Effects of fusion and anabolic steroid treatment. J. Anim. Sci. 82(Suppl. 2):201.
Pampusch, M., G. Xi, E. Kamanga-Sollo, M. White, M. Hathaway, and W. Dayton. 2004. Production of recombinant porcine IGF binding protein-5 (IGFBP-5) and its effect on proliferation of porcine embryonic myoblast cultures (PEMC) and L6 cells and on differentiation of L6 cells in the presence and absence of IGF-I . J. Anim. Sci. 82(Suppl. 2):201.
Xi, G., E.I. Kamanga-Sollo, M.S. Pampusch, M.E. White, M.R. Hathaway, and W.R. Dayton. 2004. Effect of recombinant porcine IGFBP-3 on IGF-I and Long-R3-IGF-I-stimulated proliferation and differentiation of L6 myogenic cells. J. Anim. Sci. 82(Suppl. 2):201.
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