Research Interests
Utilizing molecular
biology and muscle cell culture methodologies to study the regulation
of muscle growth during embryonic and postnatal growth of economically-important
animals, currently focusing on the two research areas: 1) Mechanism
of Action of Anabolic Steroid Growth Promoters, 2) Role
of Insulin-like Growth Factor Binding Proteins in Growth and Differentiation
of Pig Muscle Cells.
Teaching
- ANSC 3511: Animal Growth and Development
- ANSC 4096: Professional Exp (Internship) (advisor)
- ANSC 8344: Mechanisms of Hormone Action (guest lecturer)
- ANSC 8510: Graduate Seminar
Current Graduate Student and Post-doctoral Supervision
- Melvin Pagan (co-supervise),
Post-doctorate
- Ernest I. Kamanga-Sollo (co-supervise), Post-doctorate
- Mary Pampush (co-supervise), Post-doctorate
- Xi Gang (co-supervise), Ph.D. candidate
Professional
Activities and Honorary Societies
- Member,
Committee to Rewrite the NC-131 Regional Project
- Member,
Tech. Comm. NC-131 Regional Project, Molecular Mechanisms Regulating
Skeletal Muscle Growth and Differentiation
- Reviewer,
USDA Competitive Grant Proposals
- Student
Advisor, President's Distinguished Faculty Mentor Program
- Member,
American Society of Animal Science
- Phi
Kappa Phi
- Gamma
Sigma Delta
Publications
(2004-2008)
- Refereed Articles -
Dayton, W.R. and M.E. White. 2008. Cellular and molecular regulation of muscle growth and development in meat animals. J. Anim. Sci. 86(14 Suppl):E217-25.
Kamanga-Sollo, E., M.E. White, K.Y. Chung, B.J. Johnson, and W.R. Dayton. 2008. Potential role of G-protein-coupled receptor 30 (GPR30) in estradiol-17β- stimulated IGF-I mRNA expression in bovine satellite cell cultures. Domestic Anim. Endocrinol. 35:254-262.
Kamanga-Sollo, E., M.E. White, M.R. Hathaway, K.Y. Chung, B.J. Johnson, and W.R. Dayton. 2008. Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17β and trenbolone acetate- stimulated proliferation of cultured bovine satellite cells. Domestic Anim. Endocrinol. 35:88-97.
Pampusch, M.S., M.E. White, M.R. Hathaway, T.J. Baxa, K.Y. Chung, S.L. Parr, B.J. Johnson, W.J. Weber, and W.R. Dayton. 2008. Effects of implants of trenbolone acetate, estradiol, or both, on muscle IGF-I, IGF-I receptor, estrogen receptor-{alpha} and androgen receptor mRNA levels in feedlot steers. J. Anim. Sci. 86:3418-3423.
Xi, G., M.R. Hathaway, W.R. Dayton, and M.E. White. 2007. Growth factor messenger ribonucleic acid expression during differentiation of porcine embryonic myogenic cells. J. Anim. Sci. 85 143-150.
Xi, G., M.R. Hathaway, M.E. White, and W.R. Dayton. 2007. Localization of insulin-like growth factor (IGFBP)-3 in cultured porcine embryonic myogenic cells before and after TGF-beta(1) treatment. Domest. Anim. Endocrinol. Nov.;33(4):422-9.
Xi, G., E. Kamanga-Sollo, M.R. Hathaway, W.R. Dayton, and M.E. White. 2006. Effect of constitutive expression of porcine IGFBP-3 on proliferation and differentiation of L6 myogenic cells. Domest. Anim. Endocrinol. 31:35-51.
Kamanga-Sollo, E, M.S. Pampusch, M.E. White, M.R. Hathaway, and W.R. Dayton. 2005. Insulin-like growth factor binding protein (IGFBP)-3 and IGFBP-5 mediate TGF β- and myostatin-induced suppression of proliferation in porcine embryonic myogenic cell cultures. Exper. Cell Res. 311:167-176.
Xi, G., E. Kamanga-Sollo, M.R. Hathaway, W.R. Dayton, and M.E. White. 2005. Effect of constitutive expression of porcine IGFBP-3 on proliferation and differentiation of L6 myogenic cells. Domest. Anim. Endocrinol. 2005 Oct. 3.
Pampusch, M.S., G. Xi, E. Kamanga-Sollo, K.J. Loseth, M.R. Hathaway, W.R. Dayton, and M.E. White. 2005. Production of recombinant porcine IGF-binding protein-5 (IGFBP-5) and its effect on proliferation of porcine embryonic myoblast cultures (PEMC) in the presence and absence of IGF-I and Long-R3-IGF-I. J. Endocrinol. Apr. 185(1):197-206.
Kamanga-Sollo, E., M.S. Pampusch, G. Xi, M.E. White, M.R. Hathaway, and W.R. Dayton. 2004. IGF-I mRNA levels in bovine satellite cell cultures: Effects of fusion and anabolic steroid treatment. J. Cell. Physiol. 201:181-189.
Xi, G., E. Kamanga
Sollo, M.S. Pampusch, M.E. White, M.R. Hathaway, and W.R. Dayton.
2004. Effect of recombinant porcine IGFBP-3 on IGF-I and Long-R3-IGF-I stimulated proliferation and differentiation of L6 myogenic cells.
J. Cell. Physiol. 200:387-394.
- Abstracts -
Kamanga-Sollo, E., M.E. White, M.R. Hathaway, K.Y. Chung, B.J. Johnson, and W.R. Dayton. 2008. Effects of androgen and estrogen (E2) receptor blockers and E2-conjugated BSA on estrogen and trenbolone acetate-stimulated IGF-I expression in cultured bovine satellite cells. J. Anim. Sci. 86 (E-Suppl. 1):428.
Kamanga-Sollo, E., M.E. White, M.R. Hathaway, K.Y. Chung, B.J. Johnson, and W.R. Dayton. 2008 Roles of increased IGF-I expression and the estrogen, androgen and IGF-I receptors in estradiol-17β and trenbolone acetate- stimulated proliferation of cultured bovine satellite cells. J. Anim. Sci. 86 (E-Suppl. 2):427.
Pampusch, M.S., M.E. White, M.R. Hathaway, K.Y. Chung, B.J. Johnson, and W.R. Dayton. 2008. Effects of trenbolone acetate (TBA), Estradiol (E2) and combined TBA/E2 implants on muscle IGF-I and IGF-II mRNA levels in feedlot steers. J. Anim. Sci. 86 (E-Suppl. 2):427.
Xi, G., M.R. Hathaway, M.E. White, E.I. Kamanga-Sollo, M.S. Pampusch, and W.R. Dayton. 2006. Use of RNA interference (RNAi) to silence IGFBP-3 and IGFBP-5 expression in porcine embryonic myogenic cell cultures. J. Anim. Sci. Vol. 84: 29 Suppl. 15.
Xi, G., E. Kamanga-Sollo, M.R. Hathaway, M.E. White, and W.R. Dayton. 2006. Localization of IGFBP-3 and IGFBP-5 in cultured porcine embryonic myogenic cells. J. Anim. Sci. Vol. 84: 29 Suppl. 15.
Kamanga -Sollo, E., M.E. White, M.R. Hathaway, and W.R. Dayton. 2005. Insulin-like growth factor binding protein (IGFBP)-3 and IGFBP-5 mediate TGF beta- and myostatin-induced suppression of proliferation in porcine embryonic myogenic cell cultures. J. Anim. Sci. 83 (Suppl. 1):281.
Xi, G., E. Kamanga -Sollo, M.R. Hathaway, M.E. White, and W.R. Dayton. 2005. Effects of constitutive expression of porcine IGFBP-3 on proliferation and differentiation of L6 myogenic cells. J. Anim. Sci. 83 (Suppl. 1):282.
Xi, G., M.E. White, M.R. Hathaway, and W.R. Dayton. 2005. Time course of growth factor mRNA expression during differentiation of porcine embryonic myogenic cells. J. Anim. Sci. 83 (Suppl. 1):23.
Kamanga-Sollo, E., M.S. Pampusch, G. Xi, M.E. White, M.R. Hathaway, and W.R. Dayton. 2004. IGF-I mRNA levels in bovine satellite cell cultures: Effects of fusion and anabolic steroid treatment. J. Anim. Sci. 82(Suppl. 2):201.
Pampusch, M., G. Xi, E. Kamanga-Sollo, M. White, M. Hathaway, and W. Dayton. 2004. Production of recombinant porcine IGF binding protein-5 (IGFBP-5) and its effect on proliferation of porcine embryonic myoblast cultures (PEMC) and L6 cells and on differentiation of L6 cells in the presence and absence of IGF-I . J. Anim. Sci. 82(Suppl. 2):201.
Xi, G., E.I. Kamanga-Sollo, M.S. Pampusch, M.E. White, M.R. Hathaway, and W.R. Dayton. 2004. Effect of recombinant porcine IGFBP-3 on IGF-I and Long-R3-IGF-I-stimulated proliferation and differentiation of L6 myogenic cells. J. Anim. Sci. 82(Suppl. 2):201.
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