Education
- Ph.D., University
of Illinois, Quantitative Genetics
- M.S., Iowa State University, Statistics
- MS, Beijing Agricultural University, Quantitative Genetics
Research
Interests
- Statistical genetics and genomics.
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Statistical analysis for mapping disease genes and quantitative trait loci.
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Statistical procedures to apply genetics markers to animal breeding and genetics.
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Genetic diversity in domestic animals.
Software Tools
http://animalgene.umn.edu
Graduate Training
Teaching
Publications (2002-2006)
- Refereed Articles -
Gao, Y., X.X. Hu, Z.Q. Du, X.M. Deng, Y.H. Huang, J. Fei, J.D. Feng, Z.L. Liu, Y. Da, and N. Li. 2006. A genome scan for quantitative trait loci associated with body weight at different developmental stages in chickens. Animal Genetics 37:276.
Huang, Y.Q., X.M. Deng, Z.Q. Du, X. Qiu, X. Du, W. Chen, M. Morisson, S. Leroux, F.A. Ponce de León, Y. Da, and N. Li. 2006. Single nucleotide polymorphisms in the chicken Lmbr1 gene are associated with chicken polydactyly. Gene. 2006 Apr. 28.
Mao, Y., N.R. London, L. Ma, D. Dvorkin, and Y. Da. 2006. Detection of SNP epistasis effects of quantitative traits using an extended Kempthorne model. Physiological Genomics 28: 46-52.
Henderson, D., M. Thomas, and Y. Da. 2005. Conference review: Bovine genomics from academia to industry. Comparative and Functional Genomics 6:174-180.
Mao, Y. and Y. Da. 2005. Statistical power for detecting epistasis QTL effects under the F-2 Design. Genetics, Selection, Evolution 37:129-150.
Ashwell, M.S., D.W. Heyen, T.S. Sonstegard, C.P. Van Tassell, Y. Da, P.M. VanRaden, M. Ron, J.I. Weller, and H.A. Lewin. 2004. Detection of quantitative trait loci affecting milk production, health, and reproductive traits in Holstein cattle. J. Dairy Sci. 87:468-475.
Da, Y. 2003.
Statistical methods and experimental designs for mapping genes
of complex traits in domestic animals. Acta Genetica Sinica
30:1183-1192.
Garbe, J.R. and Y. Da. 2003. A software tool for the graphical visualization
of large and complex populations. Acta Genetica Sinica 30: 2293-2295.
London,
N.R, J.R. Garbe, S.M. Schmutz, M.S. Abrahamsen, and Y. Da.
2003. Linkage analysis for mapping genes of sex-influenced traits.
Mammalian Genome 14:261-267.
Patterson,
E.E., J.R. Mickelson, Y. Da, M.C. Roberts, A. McVey, D. O'Brien,
G. Johnson, and P.J. Armstrong. 2003. Clinical characteristics
and inheritance of idiopathic epilepsy in Vizslas. J.Vet. Internal
Medicine 17:319-325.
Reed, K.M., L.D. Chaves, J.R. Garbe, Y. Da, and D.E. Harry. 2003.
Allelic variation and genetic linkage of avian microsatellites
in a new turkey population for genetic mapping. Cytogenetics
and Genome Res. (In press).
Da, Y.,
J. Garbe, N. London, and J. Xu. 2002. Linkage analysis using
direct and indirect counting and relative efficiencies for codominant
and dominant loci. J. Animal Sci. 80:2528-2539.
- Invited Papers, Conference Proceedings, Research Reports -
London, N. and Y. Da. 2006. Statistical power and sample size requirement for QTL detection. In: Proc. of the 8th World Congress on Genetics Applied to Livestock Production, edited by B.D. Valente, O. Rossi de Morais, and R.V. Ventura. Belo Horizonte, Brazil: Instituto Prociência. Vol. 22: Article #18.
Ma, L., D. Dvorkin, and Y. Da. 2006. Genome-wide analysis of single-locus and epistasis SNP effects on anti-cyclic citrullinated peptide. In: Participant Contributions, Genetic Analysis Workshop 15, pp. 13-54 ~ 13-56. St. Petersburg Beach, FL. Nov. 12-15.
Mao, Y. and Y. Da. 2006. Statistical power and sample size for QTL detection using flanking markers under the f-2 design. In: Proc. of the 8th World Congress on Genetics Applied to Livestock Production, edited by B.D. Valente, O. Rossi de Morais, and R.V. Ventura. Belo Horizonte, Brazil: Instituto Prociência. Vol. 23: Article #19.
Da,
Y., N. London, and J. Xu. 2002. Partition of genotypic
variance for two linked loci under the F-2 design for
QTL mapping. Proc. 7th World Cong. Genet. Appl. Livest.
Prod., Montpellier, France 32: 737-740.
London,
N., J. Xu, J. Garbe, and Y. Da. 2002. Linkage analysis
for the hypothesized interaction between the polled
and scurred traits in cattle. Proc. 7th World Cong.
Genet. Appl. Livest. Prod., Montpellier, France 29:
485-488.
Xu,
J., N. London, J. Garbe, and Y. Da. 2002. Bias in linkage
analysis due to ignoring epistasis effects. Proc. 7th
World Cong. Genet. Appl. Livest. Prod., Montpellier,
France 32: 633-636.
- Books, Textbooks and Monographs -
Y. Da. 2007. Statistical Genetics and Genomics. Department of Animal Science, University of Minnesota.
Ma, L., D. Dvorkin, and Y. Da. 2006. EpiSNP User Manual Version 1.0w. Department of Animal Science, University of Minnesota. http://animalgene.umn.edu.
Garbe, J.R. and Y. Da. 2005. Pedigraph user manual Version 2.2. Department of Animal Science, University of Minnesota. Http://animalgene.umn.edu.
- Computer Programs -
Garbe, J.R. and Y. Da. 2004. MiniInbred, a computer program to minimize inbreeding in breeding plans. (http://animalgene.umn.edu)
Garbe, J.R. and Y. Da. 2004. Pedigraph 2.0, a computer program for pedigree/genealogy visualization of large, complex pedigrees. (http://animalgene.umn.edu)
- Abstracts -
Duan, Y., J. Garbe, N. London. L. Ma, and Y. Da. 2006. A computer program for detecting additive, dominance, imprinting, sex-influenced and the overall QTL effects. Abstract #32, Joint Ann. Mtg. of American Dairy Sci. Assoc. and American Animal Sci. Assoc., Minneapolis, MN.
Ma, L., D. Dvorkin, and Y. Da. 2006. Large scale SNP epistasis detection of complex traits using pairwise epistasis tests. IGES 15th Ann. Mtg. Nov. 16-17, St. Pete Beach, FL. p. 55.
Da, Y. and Y. Mao. 2005. Detection of epistasis effects of biallelic candidate genes of complex traits. Program and Abstract Book, p.55, Human Genome Meeting, April 18-21, 2005, Tokyo.
Garbe, J.R. and Y. Da. 2004. A computerized approach to minimize inbreeding of breeding plans. ADSA-ASAS-PSA Joint Annual Meeting, St. Louis, MO. July 25-29. p. 376.
Garbe, J.R. and Y. Da. 2004. Graphical visualization of two large complex populations using Pedigraph 2.0. ADSA-ASAS-PSA Joint Annual Meeting, St. Louis, MO. July 25-29. p. 377.
Garbe, J.R. and Y. Da. 2004. Pedigraph 2.0 - A software tool for the graphing and analysis of large complex pedigrees. ADSA-ASAS-PSA Joint Annual Meeting, St. Louis, MO. July 25-29. p. 242.
London, N.R. and Y. Da. 2004. Statistical methods to detect imprinted QTL with gender specific recombination frequencies. ADSA-ASAS-PSA Joint Annual Meeting, St. Louis, MO. July 25-29. p. 416.
Mao, Y. and Y. Da. 2004. Statistical power for detecting epistasis QTL effects under the F-2 Design. ADSA-ASAS-PSA Joint Annual Meeting, St. Louis, MO. July 25-29. p. 414.
Xu, J., J.R. Garbe, N.R. London, Y. Mao, and Y. Da. 2004. Evaluation of three statistical methods for QTL analysis. ADSA-ASAS-PSA Joint Annual Meeting, St. Louis, MO. July 25-29. p. 243.
Garbe, J.R. and Y. Da. 2003. Genealogy graphing for large complex populations:
the example of European royal genealogy data. Journal of American
Human Genetics, Supplement to Vol. 73, p. 605, 53rd Annual Meeting
of the American Society of Human Genetics.
Garbe, J.
and Y. Da. 2003. Pedigraph, a software tool for the graphical
visualization of large complex pedigrees. Final Abstracts Guide,
p. 293. Plant and Animal Genome XI, San Diego, USA, January 11-15,
2003.
Garbe, J.,
N. London, and Y. Da. 2003. Locusmap, a linkage map construction
tool for loci with various inheritance modes. Final Abstracts
Guide, p. 305. Plant and Animal Genome XI, San Diego, USA, January
11 15, 2003.
London,
N.R. and Y. Da. 2003. Optimum marker spacing for QTL detection.
Journal of American Human Genetics, Supplement to Vol. 73, p.
615, 53rd Annual Meeting of the American Society of Human Genetics.
London N.
and Y. Da. 2003. Statistical power for detecting additive and
dominance QTL effects under the reciprocal backcross and F-2
designs. Final Abstracts Guide, p. 254. Plant and Animal Genome
XI, San Diego, USA, January 11-15, 2003.
Xu, J. and
Y. Da. 2003. Genetic sampling and chiasm interference affect
QTL mapping accuracy. J. of American Human Genetics, Supplement
to Vol. 73, p. 617, 53rd Annual Meeting of the American Society
of Human Genetics.
- Theses -
London, N.R.
2004. Statistical theory and methods for mapping
gender-affected genes and quantitative trait loci. Ph.D. Thesis.
Department of Animal Science and Program in Molecular Veterinary Bioscience,
University of Minnesota.
Xu, J. 2004.
Statistical analysis for mapping linked quantitative trait loci. Ph.D. Thesis. Department of Animal Science, University of Minnesota.
Chrystal, M.A. 2003. Marker assisted selection in dairy cattle using a mixed model approach. Ph.D. Thesis. Department of Animal Science, University of Minnesota.
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