1988 Fitch Avenue
St Paul, MN 55108
United States
- Post-doctorate, University of Michigan - Physiopathology of the GI Tract
- Ph.D., Universidad Nacional Autonoma de Mexico (UNAM) - Biological Science
- B.S., Instituto Technologico de Veracruz - Biochemical Engineering
Areas of Interest
Gastrointestinal Physiology
Teaching
- CFAN 3091V: Research Proposals – From Ideas to Strategic Plans (V: Honors + Writing intensive, Fall)
- ANSC 5091: Research Proposals – From Ideas to Strategic Plans (Graduate level, Fall)
- ANSC 5626/NUTR 5626: Nutritional Physiology (Spring)
- ANSC 1901: The journal of food in your body (Fall)
- HCOL 3101H and 3102H: Honors thesis – development and Honors thesis – writing (Spring and Fall)
Research
It is often said that we are what we eat. Understanding how diet can affect physiology is my main research interest. To study the mechanisms by which diets modulate the function of the gastrointestinal tract we use in vitro and in vivo models. Our in vivo models are based on feeding animals with different diets, nutritional supplements or novel feed ingredients to evaluate how these nutritional manipulations change the epithelial cell composition, local immune response, expression of nutrient sensing molecules and hormone secretion of the digestive tract. We also use cell lines and enteroids (intestinal organoids or “mini-guts”) as in vitro models to understand the mechanisms of action of specific nutrients. We are also using swine enteroids as a model to study bacterial pathogens that cause disease in pigs. I believe that understanding the effects nutrients have on the function of the intestine will help us design better and healthier diets to improve human and animal lives.
Because research is better in collaboration, I am part of the Integrated Animal Systems Biology team.
Ongoing studies in my laboratory include:
- Effect of dietary fiber on intestinal cell differentiation and digestive function
- Effect of high fiber diets on the local intestinal immune response
- Effects of organic and inorganic zinc sources on the intestinal epithelium function
- Effects of diet viscosity on nutrient digestibility, intestinal cell differentiation, mucin production, and nutrient transporters in the swine intestine
- Use of swine enteroids as in vitro model of normal and pathological gastrointestinal physiology
- Use of enteroids to define the mechanisms of Lawsonia intracellularis pathogenesis
Publications
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Refereed Articles
Medida, R. L. (Graduate Student), Sharma, A. K., Guo, Y. (Graduate Student), Johnston, L., Urriola, P. E., Gomez, A., & Saqui-Salces, M. (2022). Dietary zinc restriction affects the expression of genes related to immunity and stress response in the small intestine of pigs. Journal of Nutritional Science, 11. doi: 10.1017/jns.2022.105
Hung, Y.-T. (Graduate Student), Song, Y., Hu, Q., Faris, R. J., Guo, J., Ma, Y., . . . Chen, C. (2022). Identification of Independent and Shared Metabolic Responses to High-Fiber and Antibiotic Treatments in Fecal Metabolome of Grow–Finish Pigs. Metabolites, 12(8), 686. doi: 10.3390/metabo12080686
Hung, Y.-T. (Graduate Student), Zhu, J., Shurson, G. C., Urriola, P. E., & Saqui-Salces, M. (2022). Decreased nutrient digestibility due to viscosity is independent of the amount of dietary fibre fed to growing pigs. British Journal of Nutrition, 127(2), 177-187. doi: 10.1017/S0007114521000866
Lozinski, B. M., Frederick, B., Li, Y., Saqui-Salces, M., Shurson, G. C., Urriola, P. E., . . . Johnston, L. J. (2022). Effects of water quality on growth performance and health of nursery pigs. Translational Animal Science, 6(1). doi: 10.1093/tas/txac002
Engevik, A.C., Krystofiak, E.S., Kaji, I., Meyer, A.R., Weis, V.G., Goldstein, A., Coutts, A.W., Melkamu, T., Saqui-Salces, M., Goldenring, J.R. 2021. Recruitment of Polarity Complexes and Tight Junction Proteins to the Site of Apical Bulk Endocytosis. Cellular and Molecular Gastroenterology and Hepatology, 12 (1), pp. 59-80.
Ding, L., Sontz, E.A., Saqui-Salces, M., Merchant, J.L. 2021. Interleukin-1β Suppresses Gastrin via Primary Cilia and Induces Antral Hyperplasia. Cellular and Molecular Gastroenterology and Hepatology, 11 (5), pp. 1251-1266.
Hung, Y.-T., Zhu, J., Shurson, G.C., Urriola, P.E., Saqui-Salces, M. 2022. Decreased nutrient digestibility due to viscosity is independent of the amount of dietary fibre fed to growing pigs. British Journal of Nutrition 28;127(2):177-187
Qiu, X., Macchietto, M.G., Liu, X., Lu, Y., Ma, Y., Guo, H., Saqui-Salces, M., Bernlohr, D.A., Chen, C., Shen, S., Chen, X. 2021. Identification of gut microbiota and microbial metabolites regulated by an antimicrobial peptide lipocalin 2 in high fat diet-induced obesity. International Journal of Obesity, 45 (1), pp. 143-154.
Medida, R.L., Vasquez, E., Lund, L.M., Gebhart, C.J., Saqui-Salces, M. 2021. Evaluation of molecules involved in intestinal changes induced by Lawsonia intracellularis infection. FASEB Journal, 35;S1:03067
Lozinski, B.M., Frederick, B., Li, Y., Saqui-Salces, M., Shurson, G.C., Urriola, P.E., Wilson, M.L., Johnston, L. J. 2021 Effects of water quality on growth performance and health of nursery pigs. Translational Animal Science, accepted 12/27/2021
Ding, L., E. A. Sontz, M. Saqui-Salces, J. L. Merchant. 2020. Interleukin-1β Suppresses Gastrin via Primary Cilia and Induces Antral Hyperplasia. Cell. Mol. Gastroenterol. Hepatol. Online ahead of print. Doi: 10.1016/j.jcmgh.2020.12.008
Engevik, A. C., A. W. Coutts, I. Kaji, P. Rodriguez, F. Ongaratto, M. Saqui-Salces, R. L. Medida, A. R. Meyer, E. Kolobova, M. A. Engevik, J. A. Williams, M. D. Shub, D. F. Carlson, T. Melkamu, and J. R. Goldenring. 2020. Editing Myosin VB Gene to Create Porcine Model of Microvillus Inclusion Disease, With Microvillus-Lined Inclusions and Alterations in Sodium Transporters. Gastroenterology. 158:2236-2249.e9. doi:10.1053/j.gastro.2020.02.034.
Hung, Y. T., Q. Hu, R. J. Faris, J. Guo, P. E. Urriola, G. C. Shurson, C. Chen, and M. Saqui‐salces. 2020. Analysis of gastrointestinal responses revealed both shared and specific targets of zinc oxide and carbadox in weaned pigs. Antibiotics. 9:1–17. doi:10.3390/antibiotics9080463.
Ortman, J., S. M. Sinn, W. R. Gibbons, M. L. Brown, J. M. DeRouchey, B. St-Pierre, M. Saqui-Salces, and C. L. Levesque. 2020. Comparative analysis of the ileal bacterial composition of post-weaned pigs fed different high-quality protein sources. Animal. 14:1156–1166. doi:10.1017/S1751731120000014.
Qiu, X., M. G. Macchietto, X. Liu, Y. Lu, Y. Ma, H. Guo, M. Saqui-Salces, D. A. Bernlohr, C. Chen, S. Shen, and X. Chen. 2021. Identification of gut microbiota and microbial metabolites regulated by an antimicrobial peptide lipocalin 2 in high fat diet-induced obesity. Int. J. Obes. 45:143–154. doi:10.1038/s41366-020-00712-2.
Resende, T. P., R. L. Medida, F. A. Vannucci, M. Saqui-Salces, and C. Gebhart. 2020. Evaluation of swine enteroids as in vitro models for Lawsonia intracellularis infection. J. Anim. Sci. 98. doi:10.1093/jas/skaa011.
Hung, Y.-T., Q. Hu, R. J. Faris, J. Guo, P. E. Urriola, G. C. Shurson, C. Chen, and M. Saqui-Salces. 2020. Analysis of Gastrointestinal Responses Revealed Both Shared and Specific Targets of Zinc Oxide and Carbadox in Weaned Pigs. Antibiotics 9:463. doi: 10.3390/antibiotics9080463
Resende TP, Medida RL, Vannucci FA, Saqui-Salces M, Gebhart C. 2020. Rapid communication: evaluation of swine enteroids as in vitro models for Lawsonia intracellularis infection. Journal of Animal Science, Accepted 12/31/209 (JAS-2019-4051)
Resende TP, Real Pereira CE, de Souza Daniel AG, Vasquez E, Saqui-Salces M, Vannucci FA, Gebhart CJ. 2019. Effects of Lawsonia intracellularis infection in the proliferation of different mammalian cell lines. Vet Micro 228:157-164
Resende TP, Medida RL, Guo Y, Vannucci FA, Saqui-Salces M, Gebhart C. 2019. Evaluation of mouse enteroids as a model for Lawsonia intracellularis infection. Veterinary research 50 (1), 1-11
Ortman J, Sinn SN, Gibbons WR, Brown ML, DeRouchey JM, St-Pierre B, Saqui-Salces M, Levesque CL. Comparative analysis of the ileal bacterial composition of post-weaned pigs fed different high-quality protein sources. Animal, accepted 12/17/2019 (Animal-18-21060)
Companioni-Napoles O, Tsao AC, Sanz-Anquela JM, Sala N, Bonet C, Pardo ML, Ding L, Simo O, Saqui-Salces M, Blanco VP, Gonzalez CA, Merchant JL. 2017. SCHLAFEN 5 expression correlated with intestinal metaplasia that progresses to gastric cancer. J Gastroenterol 52(1):39-49.
Saqui-Salces M, Tsao AC, Gillilland III MG, Merchant JL. 2017. Weight gain in mice on a high caloric diet and chronically treated with omeprazole depends on sex and genetic background. Am J Physiol Gastrointest Liver Physiol 312(1):G15-G23.
Saqui-Salces M, Luo Z, Urriola PE, Kerr BJ, Shurson GC. 2017. Effect of dietary fiber and diet particle size on nutrient digestibility and gastrointestinal secretory function in growing pigs. J Anim Sci 95(6):2640-2648. doi: 10.2527/jas.2016.1249.
Saqui-Salces M, Huang Z, Ferrandis-Vila M, Urriola PE, Shurson GC. 2017. Modulation of intestinal cell differentiation in growing pigs is dependent on the fiber source in the diet. J Anim Sci 95:1179-1190.
Merchant JL, Saqui-Salces M. 2014. Inhibition of hedgehog signaling in the gastrointestinal tract: Targeting the cancer microenvironment. Cancer Treat Rev 2014;40(1):12-21.
Essien B, Grasberger H, Romain RD, Law DL, Veniaminova NA, Saqui-Salces M, El-Zaatari M, Tessier A, Hayes MM, Yang AC, Merchant JL. 2013. ZBP-89 regulates tryptophan hydroxylase I and mucosal defense against salmonella typhimurium in mice. Gastroenterol 2013;144(7):1466-77.
Barrios-Payan JA, Saqui-Salces M, Jeyanathan M, Alcantara-Vazquez A, Castañon-Arreola M, Rook G, Hernandez-Pando R. 2012. Extrapulmonary location of Mycobacterium tuberculosis DNA during latent infection. J Infec Dis 2012;206(8):1194-205.
Saqui-Salces M, Coves-Datson E, Veniaminova NA, Waghray M, Syu LJ, Dlugosz AA, Merchant JL. 2012. Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia. PLos One 2012;7(10):e48039.
Saqui-Salces M, Dowdle WE, Reiter JF, Merchant, JL. 2012. A high fat diet regulates gastrin and acid secretion through primary cilia. The FASEB Journal 2012;26(8):3127-39.
Ortiz CS, Montante-Montes D, Saqui-Salces M, Hinojosa LM, Gamboa-Dominguez A, Hernandez-Gallegos E, Martinez-Benitez B, Solis-Pancoatl MdelR, Garcia-Villa E,Ramirez A, Aguilar-Guadarrama R, Gariglio P, Pardo LA, Stühmer W, Camacho J. 2011. Eag1 potassium channels as markers of cervical dysplasia. Oncol Rep 2011;26(6):1377-83.
Saqui-Salces M, Keeley TM, Grosse AS, Qiao XT, El-Zaatari M, Gumucio DL, Samuelson LC, Merchant JL. 2011. Gastric tuft cells express DCLK1 and are increased in hyperplasia. Histochem Cell Biol 2011;126(2):191-204.
Merchant JL, Saqui-Salces M, El-Zaatari M. 2010. Hedgehog signaling in gastric physiology and cancer. Prog Mol Biol Transl Sci 2010;96:133-56.
Saqui-Salces M, Merchant JL. 2010. Hedgehog signaling and gastrointestinal cancer. Biochim Biophys Acta 2010 Jul;1807(7):786-95. Review.
Wahgray M, Zavros Y, Saqui-Salces M, El-Zaatari M, Alamelumangapuram BC, Todisco A, Eaton KA, Merchant JL. 2010. Interleukin-1b promotes gastric atrophy through supression of Sonic Hedgehog. Gastroenterol 2010 Feb;138(2):562-72.
Cabrera-Muñoz E, González-Arenas A, Saqui-Salces M, Camacho J, Larrea F, García-Becerra R, Camacho-Arroyo I. 2009. Regulation of progesterone receptor isoforms content in human astrocytoma cell lines. J Steroid Biochem Mol Biol 2009 Jan;113(1-2):80-4.
Díaz L, Ceja-Ochoa I, Restrepo-Angulo I, Larrea F, Avila-Chávez E, García-Becerra R, Borja-Cacho E, Barrera D, Ahumada E, Gariglio P, Alvarez-Rios E, Ocadiz-Delgado R, Garcia-Villa E, Hernández-Gallegos E, Camacho-Arroyo I, Morales A, Ordaz-Rosado D, García-Latorre E, Escamilla J, Sánchez-Peña LC, Saqui-Salces M, Gamboa-Dominguez A, Vera E, Uribe-Ramírez M, Murbartián J, Ortiz CS, Rivera-Guevara C, De Vizcaya-Ruiz A, Camacho J. 2009. Estrogens and human papilloma virus oncogenes regulate human ether-à-go-go-1 potassium channel expression. Cancer Res 2009 Apr 15;69(8):3300-7.
El-Zaatari M, Saqui-Salces M, Waghray M, Todisco A, Merchant JL. 2009. Sonic hedgehog in gastric physiology and neoplastic transformation: friend or foe? Curr Opin Endocrinol Diabetes Obes 2009 Feb;16(1):60-5. Review.
Saqui-Salces M, Neri-Gomez T, Gamboa-Dominguez A, Ruiz-Palacios G, Camacho-Arroyo I. 2008. Estrogen and progesterone receptor isoforms expression in the stomach of Mongolian gerbils. World J Gastroenterol 2008 Oct 7;14(37):5701-6.
Arista-Nasr J, Gómez-Ramírez AM, Gonzáles-Romo MA, Maldonado-Martínez HA, Martínez-Benítez B, Lara C, Saqui-Salces M. 2007. Frequency of high-grade prostatic intraepithelial neoplasia in Mexican population. Rev Invest Clin 2007 Jul-Aug;59(4):234-8.
Kang W, Saqui-Salces M, Zavros Y, Merchant JL. 2008. Induction of follistatin precedes gastric transformation in gastrin deficient mice. Biochem Biophys Res Commun 2008 Nov 21;376(3):573-7.
Gamboa-Domínguez A, Ubbelohde T, Saqui-Salces M, Romano-Mazzoti L, Cervantes M, Domínguez-Fonseca C, Estreber M, Ruíz-Palacios GM. 2007. Salt intake and stress induce cell proliferation and p21 over expression in H. pylori infected Mongolian gerbils. Dig Dis Sci 2007 Jun;52(6):1517-26.
Arista-Nasr J, Gómez-Bustamante D, Aguilar-Magaña FA, Saqui-Salces M, Martínez-Benítez B. 2006. Hallazgos patológicos en 100 biopsias prostáticas por punción y diagnóstico original de benignidad. Rev Invest Clin 2006;58(2):88-93.
Saqui-Salces M, Martinez-Benitez B, Gamboa-Dominguez A. 2006. EBV+ lymphoepithelial carcinoma of the parotid gland in Mexican Mestizo patients with chronic autoimmune diseases. Pathol Oncol Res 2006;12(1):41-5.
Saqui-Salces M, Rocha-Gutierrez BL, Barrios-Payan JA, Ruiz-Palacios G, Camacho-Arroyo I, Gamboa-Domingues A. 2006. Effects of estradiol and progesterone on gastric mucosal response to early Helicobacter pylori infection in female gerbils. Helicobacter 2006;11(2):126-130.
Velazques-Fernandez D, Laurell C, Saqui-Salces M, Pantoja JP, Candanedo-Gonzalez F, Reza-Albarran A, Gamboa-Dominguez A, Herrera MF. 2006. Differential RNA expression profile by cDNA microarray in sporadic primary hyperparathyroidism (pHPT): primary parathyroid hyperplasia versus adenoma. World J Surg 2006;30(5):705-713.
De-León-Mazariegos R, Canedo-Patzi M, Pérez-Enríquez B, Candanedo-Gonzalez F, Saqui-Salces M, Gamboa-Domínguez A, Rull-Rodrigo JA. 2004. Baja capacidad de galectina-3 para discriminar lesiones tiroideas. Rev Invest Clin 2004;56(5):623-628.
Díaz-Rubio JL, Duarte-Rojo A, Saqui-Salces M, Gamboa-Domínguez A, Robles-Díaz G. 2004. Cellular proliferative fraction measured with Topoisomerase IIa predicts malignancy in endocrine pancreatic tumors. Arch Pathol Lab Med 2004;128:426-429.
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Non-Refereed Articles
Hung. Y. T., J. Zhou, G.C. Shurson, P.E. Urriola, and M. Saqui-Salces. Decreased nutrient digestibility due to viscosity is independent of the amount of dietary fiber fed to growing pigs
Mielke J, Ma Y, Saqui-Salces M, Urriola PE, Chen C, Shurson GC. 2015. Potential use of microalgae products in swine diets. UMN Swine Ext. Newsletter, Nov.
Saqui-Salces M. 2014. Calf health and gastrointestinal development. Progressive Dairyman 19:80-81. Nov. 24. Available online.
Prieto GA, Villamar-Cruz O, Saqui-Salces M, Neri-Gómez T, Almaraz-Nieves A, Hernández-Molina V, Valdez Rodríguez H, Camacho-Arroyo I. 2003. ¿Cómo actúan las hormonas esteroides? Educación Química 14: 196-201. (Spanish)
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Book Chapters
Merchant JL, Saqui-Salces M, El Zaatari M. 2010. Hedgehog signaling in gastric physiology and cancer. In: Progress in Molecular Biology and Translational Science Vol. 96: Development, Differentiation, and Disease of the Luminal Gastrointestinal Tract. K. Kaestner, Ed. Elsevier. 133-156. ISBN: 978-0-12-381280-3. Peer reviewed.
Saqui-Salces M and El Zaatari M. 2009. Stomach: An integrative view of endocrine regulation in normal physiology and gastric cancer. In: Advances in Selected Topics in Endocrinology. I. Camacho-Arroyo, Ed. Research Signpost, Kerala, India. 223-237. ISBN: 978-81-308-0363-0. Peer reviewed.
Camacho-Arroyo I, Neri-Gómez T, Saqui-Salces M y González-Arenas A. 2008. Principios básicos de la centrifugación. In: Técnicas de Laboratorio en Biología Celular y Molecular. G. González-Morán, Ed. AGT Editores. México, D. F. México. 99-110. ISBN: 978-968-463-138-0.
Gamboa-Domínguez A, Saqui-Salces M, Cerbón M and Camacho-Arroyo I. 2007. Role of sex steroid hormones in gastric and thyroid cancer. In: Advances in Cancer Research at UNAM. J. Mas-Oliva, Ed. Manual Moderno. México, D. F. México. 139-150. ISBN: 970-32-4283-9. Peer reviewed
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Invited Papers, Conference Proceedings, Presentations
Saqui-Salces M. “Modeling gastrointestinal physiology”, presented to Novus International, Inc. Research and development group. Feb. 17, 2021.
Saqui-Salces M. "Modeling gastrointestinal physiology” Seminar presentation. Department of Animal and Food Sciences. University of Delaware. Sept 28,2020
Hung YT, Zhu J, Shurson GC, Saqui-Salces M, Urriola PE. 2019. Influence of viscosity and fiber on nutrient digestibility and intestinal physiology in growing pigs. ASAS Midwest Meeting, Omaha, Nebraska. March 2-4.
Guo Y, Wilson M, Saqui-Salces M. 2017. Intestinal epithelial responses to organic and inorganic sources of zinc. 78th Minnesota Nutrition Conf, Mankato, MN. Sep. 20-21 (Poster presentation).
Saqui-Salces M. 2017. Gastro-intestinal responses to diet. Presented to UMN Research Animal Resources Group, St Paul, MN. Feb 15.
Saqui-Salces M. 2017. Gut health fact check. Presented at Department of Animal Science Faculty Seminar, St Paul, MN. June 9.
Saqui-Salces M. 2017. Research update: Carbohydrase effects on dietary fiber and gut function. Proc, 78th Minnesota Nutrition Conf, Mankato, MN. Sep 21. p. 177.
Huang Z, Saqui-Salces M, Urriola PE, Shurson GC. 2015. Differential effect of fiber type and fermentability on the intestinal immune response of pigs fed high-fiber diets. AD Leman Conf, Chinese Swine Industry Preconf, Minneapolis, MN. Sep 20.
Saqui-Salces M. 2015. Endocrine function of the gastrointestinal tract and its role on metabolism. Winter Ext Mtg, St Paul, MN. Jan.
Sinn SM, Gibbons WR, Brown M, DeRouchey JM, Saqui-Salces M, Levesque CL. 2015. Assessment of digestive function in weaned pigs fed microbially-converted soybean meal or fish meal with or without acidifier. Digest Physiol of Pigs, Kliczkóv, Poland. May 19-21.
Saqui-Salces M. 2014. Nutritional approaches and gastrointestinal health and physiology. 75th Minnesota Nutrition Conf, Prior Lake, MN. Sep 17.
Saqui-Salces M, Dowdle WE, Reiter JF, Merchant JL. 2011. Primary cilia participate in gastric endocrine response to food intake. FASEB Summer Res Conf, Gastrointestinal Tract XIV, Steamboat Springs, CO. Aug.
Saqui-Salces M, Merchant JL. 2010. Gastric epithelial cells express primary cilia. Keystone Symposium: Cilia, Development and Human Disease, Monterey, CA. Feb.
Merchant JL, Veniaminova N, Saqui-Salces M, Tessier A, Adams R, Zhang M. 2009. Transcription factor ZBP-89 interacts with ATM to specify enterochromaffin cell differentiation. FASEB Summer Res Conf, Gastrointestinal Tract XIII, Snowmass, CO. Aug.
Saqui-Salces M, Merchant JL. 2009. Differential expression of primary cilia in the mouse gut. FASEB Summer Res Conf, Gastrointestinal Tract XIII, Snowmass, CO. Aug.
Jacinto-Cortes I, Saqui-Salces M, Candanedo-Gonzalez F. 2006. Expresion inmunohistoquimica de Ki-67, EGF-R y ciclina D1 en carcinoma papilar de tiroides bien diferenciado en pacientes pre y post menopausicas. XLIX Congreso Anual de la Asociacion Mexicana de Patologos, AC, Veracruz, Ver, Mexico. Apr.
Saqui-Salces M, Camacho-Arroyo I, Ruiz-Palacios G, Gamboa-Dominguez A. 2005. Efecto protector de 17-b-estradiol y progesterona sobre las celulas G en jerbos hembra infectados con H. pylori. IV Congreso Anual de la Federacion de Anatomia Patologica de la Republica Mexicana, Puebla, Pue, Mexico. Nov.
Saqui-Salces M. 2004. Efectos del estradiol y la progesterona en la proliferacion y apoptosis de la mucosa gastrica en jerbos infectados por Helicobacter pylori. XLVII Congreso Nacional de la Sociedad Mexicana de Ciencias Fisiologicas, Veracruz, Ver, Mexico. Aug.
Candanedo F, Saqui-Salces M, Gamboa-Domínguez A. 2003. La ausencia de E-cadherina no se asocia a evolución más agresiva en CPT-BD. Estudio inmunohistoquímico con microarreglo de tejidos. Congreso Latinoamericano de Patología, Quito, Ecuador. Oct.
Saqui-Salces M, Gamboa-Domínguez A, Ubbelohde T, Romano Mazzotti L, Cervantes Gonzáles M, Domínguez Fonseca C, Estreber ML, Hernández González R, Ruiz Palacios GM. 2003. Sinergismo de ingesta alta de sal y estrés en lesiones de antro inducidas por H. pylori, proliferación celular y sobreexpresión de p21 en jerbos. Congreso Latinoaméricano de Patología, Quito, Ecuador. Oct.
Diaz-Rubio JL, Gamboa-Dominguez A, Duarte-Rojo A, Saqui-Salces M, Robles-Diaz G. 2002. La proliferacion celular sobre la angiogenesis y la apoptosis determina la malignidad en tumores endocrinos del pancreas. Congreso Nacional de Gastroenterologia, Queretaro, Qro, Mexico. Nov.
Gamboa Domínguez A, Castro H, Saqui-Salces M, Bornstein Quevedo L, Vela T, De la Garza L, León E. 2001. Neoplasias epiteliales del timo (NET): correlación de la clasificación de la OMS, índice de proliferación celular (IP) con etapa clínica y sobrevida. XXIII Congreso Latinoamericano de Patología, Managua, Nicaragua. Nov.
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Abstracts
Medida, R.L., Vasquez, E., Lund, L.M., Gebhart, C.J., Saqui-Salces, M. 2021. Swine enteroids reproduce gene expression changes observed in Lawsonia intracellularis- infected pig intestine, CRWAD, Chicago, Illinois. December 3rd to 7th, 2021.
Medida, R.L., Vasquez, E., Lund, L.M., Gebhart, C.J., Saqui-Salces, M. 2021. Evaluation of molecules involved in intestinal changes induced by Lawsonia intracellularis infection, Experimental Biology, April 27-30, 2021 (virtual).
Hung. Y. T., J. Zhou, G.C. Shurson, M. Saqui-Salces, and P.E. Urriola. 2020. Influence of viscosity and fiber on nutrient digestibility and intestinal physiology in growing pigs. J. Anim. Sci. 98, Suppl. 3:67-68. doi: 10.1093/jas/skaa054.121
Lozinski, B., B. Frederick, A. Hillbrands, Y. Li, M. Saqui-Salces, G. C. Shurson, P. E. Urriola, M. Wilson, and L. Johnston. 2020. Effects of Water Quality on Nursery Pig Performance and Health. Anim. Sci. 98, Suppl. 3:89. doi:10.1093/jas/skaa054.156
Engevik AC, Coutts A, Saqui-Salces M, Kaji I, Medida RL, Williams J, Carlson DF, Melkamu T, Goldenring JR. 2019. Gene Editing of Swine Myosin Vb Induces Microvillus Inclusion Disease and Loss of Apical Sodium Transporters with Maintenance of CFTR in Enterocytes. The FASEB Journal 33; Suppl. 1:869.14-869.14
Medida RL, Sharma AK, Guo Y, Wilson M, Gomez A, Saqui-Salces M. 2019. Dietary Zinc Supplementation from Organic and Inorganic Sources Induce Differential Intestinal Gene Expression in Swine. The FASEB Journal 33; Suppl. 1:lb547- lb547
Ding L, Li Q, Munoz A, Saqui-Salces M, Merchant JL. 2019. Primary Cilia Transduce Inflammatory and Hedgehog Signaling to Modulate Gastrin Expression and Antral Hyperplasia. Gastroenterology 156 (6), S-203
Engevik AC, Coutts A, LeBlanc C, Saqui-Salces M, Kaji I, Carlson DF, Melkamu T, Goldenring JR. 2019. Role of Myosin Vb in Trafficking of Apical Membrane Proteins in Hepatocytes. Gastroenterology 156 (6), S-1184
Guo Y, Hanson A, Wang L, Kerr B, Urriola PE, Shurson G, Saqui-Salces M, Chen C. 2019. Characterization of oxidized oil-elicited disruption of amino acid metabolism in nursery pigs through metabolomic analysis. Journal of Animal Science 97 (Supplement_2), 177-177
Ferrandis Vila M, Zeng, Z, Urriola PE, Shurson GC, Saqui-Salces M. 2017. Cytokine profile in ileal and colonic tissue of pigs is modulated by different fiber sources with and without multi-carbohydrase enzyme supplementation. FASEB J 31:1044.1.
Fung L, Shurson GC, Urriola PE, Saqui-Salces M. 2017. Effects of mycotoxin-contaminated high-protein distiller's dried grains and mycotoxin mitigation additive on growth performance and plasma glucagon-like peptide-1 concentration of growing-finishing pigs. J Anim Sci 95(Suppl. 2):140-141 (Abstr. 290).
Hung YT, Guo J, Hu Q, Faris R, Urriola PE, Chen C, Saqui-Salces M, Shurson GC. 2017. Physiological responses of feeding zinc oxide and an antibiotic to nursery pigs: Integrated analysis of immune response, morphological changes, and metabolic profile. University/Industry Consortium, University of Minnesota, Minneapolis, MN. Oct 31.
Kurtz JF, Chen C, de Nanclares MP, Trudeau M, Yao D, Saqui-Salces M, Urriola PE, Mydland LT, Shurson GC, Overland M. 2017. Effects of rapeseed feeding on swine metabolome. J Anim Sci 95(Suppl 2):124-125 (Abstr 258).
Mielke JA, Urriola PE, Saqui-Salces M, Johnston LJ, Shurson GC. 2017. Growth performance of nursery pigs fed microalgae carbohydrate product. J Anim Sci 95(Suppl 2):103 (Abstr 215).
Resende TP, Kupiec C, Vannucci FA, Saqui-Salces M, Gebhart C. 2017. Evaluation of mouse enteroid as a model for Lawsonia intracellularis infection. Proc, ASM/ASV Conf on Interplay of Viral and Bacterial Pathogens, Bethesda, MD. May 1-4. S5:3.
Saqui-Salces M. 2017. Carbohydrase effects on dietary fiber and gut function. Proc, 78th Minnesota Nutrition Conf, Mankato, MN. Sep 20-21. p. 177.
Trudeau MP, Kupiec C, Ferrandis Vila M, Urriola PE, Shurson GC, Saqui-Salces M. 2017. Development of swine enteroids: A novel tool for animal science research. 78th Minnesota Nutrition Conf, Mankato, MN. Sep 20-21. (Abstract submitted for poster competition; poster placed 3rd)
Trudeau MP, Urriola PE, Shurson GC, Saqui-Salces M. 2017. Development of swine enterioids: A novel tool for animal science research. Symp on Gut Health in Production of Food Animals, St Louis, MO. Nov 13-15.
Trudeau MP, Urriola PE, Shurson GC, Saqui-Salces M. 2017. Development of swine enteroids: A novel tool for animal science research. University/Industry Consortium, University of Minnesota, Minneapolis, MN. Oct 31.
Wang L, Yao D, Urriola P, Saqui-Salces M, Shurson G, Chen C. 2017. Identification of activation of tryptophan-NAD+ pathway as a central metabolic response to chemical stress from feeding thermally-oxidized soybean oil in mouse through metabolomics-based biochemical analysis. FASEB J 31:1_suppl (Abstr 148.4).
Saqui-Salces M, Huang ZM, Urriola PE, Shurson GC. 2015. Differential effect of fiber type and fermentability on the intestinal immune response of pigs fed high-fiber diets. Gastroenterology Vol. 148(4) Suppl. 1, pp. S530-S530.
Saqui-Salces M, Huang ZM, Urriola PE, Shurson GC. 2015. Impact of high-fiber diets of different fermentability on intestinal cell differentiation. Gastroenterology Vol. 148(4) Suppl. 1, pp. S344-S344.
Saqui-Salces M, Luo ZH, Kerr BJ, Urriola PE, Shurson, GC. 2015. Effect of dietary lipid, fiber type, and particle size on the gastrointestinal endocrine function and nutrient utilization in growing pigs. Gastroenterology Vol. 148(4) Suppl. 1, pp. S344-S344.
Saqui-Salces M. 2014. Nutritional approaches and gastrointestinal health and physiology. Proc. 75th Minnesota Nutrition Conf., Prior Lake, MN. Sep. 17-18.
Saqui-Salces M, Tsao AC, Merchant JL. 2014. Chronic omeprazole treatment induces weight gain in mice when combined to high energy diet. Gastroenterology Vol. 146, Issue 5, S-501.
Todt J, Tsao AC, Hayes MM, Veniaminova NA, Saqui-Salces M, Merchant JL. 2014. Generation of gastric carcinoids in mice after targeted deletion of men1 and somatostatin gene loci. Gastroenterology Vol. 146, Issue 5, S-300.
Saqui-Salces M, Merchant JL. 2013. Cell-specific deletion of primary cilia on G-cells alters food induced gastrin secretion. Gastroenterology Vol. 144, Issue 5, Suppl. 1, p. S-8.
Saqui-Salces M, Merchant JL. 2012. Primary cilia regulate gastric endocrine response to food. Reg Peptides 2012 Vol. 177, Suppl. 1, S31.
Saqui-Salces M, Merchant JL. 2013. Primary cilia regulate gastrin secretion in GLUTag cells. FASEB J April 9, 2013 27:1160.4.
Saqui-Salces M, Dowdle WE, Reiter JF, Merchant JL. 2012. Food intake stimulates gastrin and acid secretion through primary cilia. Gastroenterology 2012 Vol. 142, Issue 5, Suppl. 1, pp. S-49-S-50.
Saqui-Salces M, Merchant JL. 2012. Ingestion of a high fat diet sensed by primary cilia lowers gastrin secretion. Gastroenterology 2012 Vol. 142, Issue 5, Suppl. 1, p. S-857.
Covés-Datson E, Saqui-Salces M, Waghray M, Merchant JL, Dlugosz A. 2011. Induction of follistatin in metaplastic antra of gastrin null mice correlates with increased hedgehog signaling. Gastroenterology 2011 Vol. 140, Issue 5, Suppl. 1, p. S-92.
Grasberger H, Saqui-Salces M, El-Zaatari M, Tessier A, Hayes MM, Merchant JL. 2011. Transcription factor ZBP-89 is required for tryptophan hydroxylase 1 gene expression and serotonin production. Gastroenterology 2011 Vol. 140, Issue 5, Suppl. 1, pp. S-480-S-481.
Saqui-Salces M, Dowdle WE, Reiter JF, Merchant JL. 2011. Disruption of primary cilia induces gastric mucosal hyperplasia. Gastroenterology 2011 Vol. 140, Issue 5, Suppl. 1, p. S-93. Oral presentation.
Saqui-Salces M, Dowdle WE, Reiter JF, Merchant JL. 2011. Mice with gastric hyperplasia develop obesity, fatty liver and large pancreatic islets. 2011. Gastroenterology 2011 Vol. 140, Issue 5, Suppl. 1, p. S-332.
Saqui-Salces M, Keeley TM, Samuelson LC, Gumucio DL, Merchant JL. 2011. Gastro-intestinal tuft cells are DCLK1 positive, and appear late in development. Gastroenterology 2011 Vol. 140, Issue 5, Suppl. 1, p. S-148. Oral presentation.
Saqui-Salces M, Merchant JL. 2011. Differential response of primary cilia to food and distension in the gastric corpus and antrum. Gastroenterology 2011 Vol. 140, Issue 5, Suppl. 1, p. S-323.
Saqui-Salces M, El Zaatari M, Hayes MM, Veniaminova N, Hockeimer WD, Merchant JL. 2010. Colocalization of Atm and ZBP-89 to enterochromaffin cells. Gastroenterology 2010 Vol. 138, Issue 5, Suppl. 1, p. S-98. Oral Presentation.
Saqui-Salces M, Merchant JL. 2010. Food ingestion modulates primary cilia quantity on gastric epithelial cells. Gastroenterology 2010 Vol. 138, Issue 5, Suppl. 1, p. S-407.
Veniaminova N, Saqui-Salces M, Merchant JL. 2010. Disheveled inhibits ZBP-89 activation of p21Wa and OLFM4, an intestinal notch target. Gastroenterology 2010 Vol. 138, Issue 5, Suppl. 1, p. S-140. Oral presentation.
El Zaatari M, Saqui-Salces M, Waghray M, Tessier A, Bai L, Merchant JL. 2009. Sonic hedgehog regulates mucous neck to zymogenic cell lineage specification. Disease Week 2009. Chicago, IL. Gastroenterology 2009;136(5):A-133.
Saqui-Salces M, Merchant JL. 2009. Gastric epithelial cell express primary cilia. Digestive Disease Week 2009. Chicago, IL. Gastroenterology 2009;136(5):A-396. Poster of distinction.
Saqui-Salces M, Merchant JL. 2009. IL-1b induces specific gastric mucous cell differentiation and proliferation. Digestive Disease Week 2009. Chicago, IL. Gastroenterology 2009;136(5):A-401. Poster of distinction.
Gamboa-Dominguez A, Saqui-Salces M, Luqueno V, Ortiz S, Ruiz-Palacios G. 2007. Heterotopic proliferative glands in H. pylori infected Mongolian gerbils preserve DNA repair enzyme MSH-6. XX International Workshop of the European Helicobacter Study Group. Sophia, Turkey. Oct 12-14, 2007. Helicobacter.
Candanedo-Gonzalez FA, Cordova-Uscanga C, Alvarado-Cabrero I, Saqui-Salces M, Gamboa-Dominguez A. 2006. E-cadherin abnormalities, but not epidermal growth factor receptor (EGF-R) expressionn correlates with adenoid cystic carcinoma recurrence. Atlanta, Georgia, Feb 11-17, 2006. Lab Invest 2006;86 (Suppl. 1):205A.
Candanedo-Gonzalez FA, Saqui-Salces M, Rocha BA, Gamboa-Domínguez A. 2005. Hormonal status correlates with EGF-R or Ki-67 expression in women with differentiated papillary thyroid carcinoma (D-PTC). 94th Annual Meeting of the United States and Canadian Academy of Pathology. San Antonio, TX, USA. Feb 26-March 4, 2005. Lab Invest 2005;85(1):89A.
Saqui-Salces M, Camacho-Arroyo I, Ruiz-Palacios G, Gamboa-Dominguez A. 2005. Protective effect of 17-b-estradiol and progesterone on G cells in Helicobacter pylori-infected female Mongolian gerbils. XVIII International Workshop on Gastrointestinal Pathology and Helicobacter. Copenhagen, Denmark. October 12-14, 2005. Helicobacter 2005:10;546.
Candanedo-González FA, Saqui-Salces M, Gamboa-Domínguez A. 2004. Epidermal growth factor receptor (EFG-R) overexpression, but not E-Cadherin (CDH1) abnormalities correlate with postmenopausal differentiated papillary thyroid carcinoma (D-PTC). 93rd Annual Meeting of the United States and Canadian Academy of Pathology. Vancouver, Canada. March 6-12, 2004. Mod Pathol 2004;17(1):102A.
Gamboa-Domínguez A, Saqui-Salces M, Candanedo-Gonzalez FA, Näririg N, Becker KF, Luber B, Fend F. 2004. Inverse correlation of E-Cadherin (CDH1) and epidermal growth factor receptor (EGF-R) in papillary thyroid carcinoma. 93rd Annual Meeting of the United States and Canadian Academy of Pathology. Vancouver, Canada. March 6-12, 2004. Mod Patol 2004;17(1):104A.
Saqui-Salces M, Camacho-Arroyo I, Cerbón-Cervantes MA, Ruiz-Palacios G, Gamboa-Domínguez A. 2004. Influence of 17-b-estradiol (E2) and progesterona (P4) in H. pylori-gastric mucosa interactions in Mongolian gerbils. XVII Internacional Workshop on Gastrointestinal Pathology and Helicobacter. Vienna, Austria. Sep 22-24, 2004. Helicobacter 2004:9;592.
Candanedo F, Saqui-Salces M, Gamboa-Domínguez A. 2003. La ausencia de E-cadherina no se asocia a evolución más agresiva en CPT-BD. Estudio inmunohistoquímico con microarreglo de tejidos. Congreso Latinoamericano de Patología. Quito, Ecuador 20-24 Oct. 2003.
Gamboa-Dominguez A, Ubbelhode T, Romano-Mazzotti L, Cervantes M, Saqui-Salces M, Dominguez C, Estreber ML, Hernandez R, Ruiz-Palacios G. 2003. Synergism of high-salt intake and stress in H. pylori-induced gastric antral lesions, cell proliferation and p21 overexpression in Mongolian gerbils. XVI International Workshop of the European Helicobacter Study Group. Stockholm, Sweden. Sep 3-6, 2003. Helicobacter 2003; 8:430.
Saqui-Salces M, Gamboa-Domínguez A, Ubbelohde T, Romano Mazzotti L, Cervantes Gonzáles M, Domínguez Fonseca C, Estreber ML, Hernández González R, Ruiz Palacios GM. 2003. Sinergismo de ingesta alta de sal y estrés en lesiones de antro inducidas por H. pylori, proliferación celular y sobreexpresión de p21 en jerbos. Congreso Latinoaméricano de Patología. Quito, Ecuador, Oct 20-24, 2003.
Gamboa Domínguez A, Castro H, Saqui-Salces M, Bornstein Quevedo L, Vela T, De la Garza L, León E. 2001. Neoplasias epiteliales del timo (NET): correlación de la clasificación de la OMS, índice de proliferación celular (IP) con etapa clínica y sobrevida. XXIII Congreso Latinoamericano de Patología, Managua, Nicaragua, Nov 2001.
Gamboa Domínguez A, Chavarri-Guerra Y, Saqui-Salces M, Pérez SLG, Gabilondo F. 2001. High expression of Epstein Barr virus in testicular germ cell tumor of immunodeficient patients. 18th European Congress of Pathology, Berlin, Germany. Virchows Archiv 2001;439:397.
Gamboa Domínguez A, Chavarri Guerra Y, Saqui-Salces M, Pérez Santos LG. 2001. High expression of EBV in testicular germ cell tumors in immunocompromised patients. 90th Annual Meeting of the United States and Canadian Academy of Pathology. Atlanta, GA, USA. March 6, 2001. Mod Pathol 2001; 14:108A.
Saqui-Salces M, Gamboa Domínguez A. 2001. Adjacent mucosal changes in EBV associated gastric adenocarcinoma. 18th European Congress of Pathology, Berlin, Germany. Virchows Archiv 2001;439:292-293.
Honors and Awards
- 2019 – Above and Beyond Award, Department of Animal Science, University of Minnesota
- 2018 - Award for Faculty Contribution to Honors Education
- 2017 - Team Achievement Award, Animal Systems Biology Team, Department of Animal Science, University of Minnesota
- 2009 - Poster of distinction Digestive Diseases Week. Title: IL-1b induces specific gastric mucous cell differentiation and proliferation.
- 2009 - Poster of distinction Digestive Diseases Week. Title: Gastric epithelial cell express primary cilia.
- 2007 - Canifarma Award to Clinical Research (Mexico). Title: Deteccion temprana de lesiones intraepiteliales cervicales de bajo y alto grado (Early detection of low and high grade intraepithelial lesions of the cervix). Authors: Ortíz-Arce C, Montante-Montes D, Saqui-Salces M, Hinojosa L, Hernández-Gallegos E, Gamboa-Domínguez A, Pardo L, Stúhmer W, Camacho, J.
- 2006 - PhD, graduated with Honor mention, UNAM, Mexico.