Laura J. Mauro

Associate Professor-Cellular Physiology
495F AnSc/VetMed
1988 Fitch Avenue
St. Paul, MN 55108-6014
+1 612 624 6274

Education

  • Postdoctorate, Michigan Medical Center, 1991, Cell Signaling
  • Ph.D., University of Minnesota, 1990, Animal Physiology/Neuroscience
  • M.S., University of Minnesota, 1983, Veterinary Physiology

Research Interests

The phosphorylation and dephosphorylation of cellular proteins is a critical component in the regulation of all biological processes. The signaling molecules known as protein tyrosine kinases and phosphatases are essential mediators of this type of regulation. They are responsible for maintaining a steady-state level of specific phosphotyrosine proteins which will influence the functional state of the cell. Mutations or dysfunction in these molecules is associated with many animal and human diseases including deadly bacterial infections, diabetes, and cancer. My laboratory studies the importance of the tyrosine phosphatases (PTPs) in cell proliferation and differentiation. We are interested in how certain PTPs regulate cell growth and differentiation during the development and remodeling of bone. In addition, we are exploring whether these molecules could serve as drug targets for skeletal disorders, such as osteoporosis, in animals and humans.

Teaching

  • ANSC 3305: Reproductive Biology in Health and Disease
  • ANSC 4009W: Undergraduate Senior Thesis: Science in Agriculture
  • ANSC 4096: Professional Experience Program - Internship (mentor)
  • ANSC 4305/5305: Companion and Wild Species Reproduction
  • ANSC 8211: Animal Growth and Development
  • ANSC / CMB 8344: Mechanisms of Hormone Action

Outreach

  • Life Sciences Undergraduate Research Program (LSSURP)
  • Undergraduate Research Opportunity Grant Program (UROP)
  • Minority Scholar Program

Honors & Awards

  • National Institutes of Health James A. Shannon Director's Award - 1997-99
  • U.S. Patent No. 5,821,084 - "Osteoblast-testicular protein tyrosine phosphatase" (American Home Products Corp., Wyeth-Ayerst Research and The Regents of the University of Michigan) - 1998
  • New Investigator Travel Grant - The Endocrine Society - 1996
Dr. Laura Mauro